Effects of light-emitting diode therapy (LEDT) on cardiopulmonary and hemodynamic adjustments during aerobic exercise and glucose levels in patients with diabetes mellitus: A randomized, crossover, double-blind and placebo-controlled clinical trial

Author(s):Show less -

Francisco, Cristina de Oliveira ^[1] ; Beltrame, Thomas ^[2] ; Hughson, Richard L. ^{[3, 2]} ; Milan-Mattos, Juliana Cristina ^[1] ; Ferroli-Fabricio, Amanda Magdalena ^[1] ; Benze, Benedito Galvao ^[4] ; Ferraresi, Cleber ^[5] ; Parizotto, Nivaldo Antonio ^[1] ; Bagnato, Vanderlei Salvador ^[6] ; Borghi-Silva, Audrey ^[1] ; Porta, Alberto ^{[7, 8]} ; Catai, Aparecida Maria ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Physiotherapy, Cardiovasc Phys Therapy Lab, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Waterloo, Fac Appl Hlth Sci, 200 Univ Ave W, Waterloo, ON N2L 3G1 - Canada

^[3] Schlegel Univ Waterloo, Res Inst Aging, 250 Laurelwood Dr, Waterloo, ON N2J 0E2 - Canada

^[4] Univ Fed Sao Carlos, Dept Stat, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[5] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, 40 Blossom St, Boston, MA 02114 - USA

^[6] Univ Sao Paulo, Dept Phys, Av Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil

^[7] Univ Milan, Dept Biomed Sci Hlth, Via C Pascal 36, I-20133 Milan - Italy

^[8] IRCCS Policlin San Donato, Dept Cardiothorac Vasc Anesthesia & Intens Care, Via F Fellini 4, I-20097 Milan - Italy

• Document type: Journal article
• Source: COMPLEMENTARY THERAPIES IN MEDICINE; v. 42, p. 178-183, FEB 2019.
• Web of Science Citations: 2

Abstract

The aim of this study was to evaluate the acute effects of light-emitting diode therapy (LEDT) on cardiopulmonary adjustments and muscle oxygenation dynamics during transition to moderate exercise, as well as in glucose and lactate levels in patients with type 2 diabetes mellitus (T2DM). Sixteen individuals with T2DM (age 55.1 +/- 5.4 years) performed four separate tests receiving LEDT or placebo in random order, at intervals of at least 14 days. A light-emitting diode array (50GaAIAs LEDs, 850nm, 75mW per diode) was used to perform LEDT bilaterally on the quadriceps femoris and triceps surae muscles for 40s at each site. After, a moderate cycling exercise was performed and oxygen uptake, muscular deoxyhemoglobin, heart rate and cardiac output were measured. Lactate and glucose levels were measured before LEDT/placebo and after the exercise. The LEDT decreased the glucose levels after the exercise compared with values before LEDT (173.7 +/- 61.0 to 143.5 +/- 53.5 mg/dl, P =0.02) and it did not affect the cardiopulmonary and hemodynamic adjustments in exercise, as well as lactate levels in both groups. In conclusion, the LEDT in combination with moderate exercise acutely decreased the glucose levels in men with T2DM. (AU)

• FAPESP's process: 15/20512-1 - Evaluation of acute effect of phototherapy with Light Emitting Diode (LED) on muscle deoxygenation and pulmonary oxygen uptake kinetics in patients with diabetes Mellitus
• Grantee: Cristina de Oliveira Francisco
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 13/07953-3 - Evaluation of acute effect of phototherapy with Light Emitting Diode (led) on muscle and pulmonary oxygen consumption in patients with diabetes mellitus
• Grantee: Aparecida Maria Catai
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08183-7 - Acute effect of phototherapy with light emitting diode (LED) on muscle and pulmonary oxygen consumption in men with diabetes mellitus and healthy
• Grantee: Cristina de Oliveira Francisco
• Support Opportunities: Scholarships in Brazil - Doctorate