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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis

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Author(s):
Fumagalli, Fernando [1] ; Gil de Melo, Shaiani Maria [1] ; Ribeiro, Camila Maringolo [2] ; Solcia, Mariana Cristina [2] ; Pavan, Fernando Rogerio [2] ; Emery, Flavio da Silva [2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo FCFRP USP, Dept Pharmaceut Sci, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N Campus Univ USP, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Biol Sci, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km01 S-N, Campos Ville, BR-14800903 Araraquara - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Bioorganic & Medicinal Chemistry Letters; v. 29, n. 8, p. 974-977, APR 15 2019.
Web of Science Citations: 0
Abstract

Identification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo {[}2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a C-H amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo {[}2,3-b] pyridine core through this reaction. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 17/21146-4 - Heterocyclic chemistry and epigenetic for the development of library of compounds for medicinal chemistry purposes.
Grantee:Flavio da Silva Emery
Support type: Regular Research Grants
FAPESP's process: 15/06588-5 - Development of library of heterocyclic fragments based on new heteroaromatic cores
Grantee:Fernando Fumagalli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/00163-0 - Development and search of new antimicrobials against Tuberculosis: from screening to pre-clinical studies in vivo
Grantee:Fernando Rogério Pavan
Support type: Regular Research Grants