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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

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Author(s):
Gimenez, Valeria M. M. [1] ; Alvarenga, Tavane A. [1] ; Groppo, Milton [2] ; A e Silva, Marcio L. [1] ; Cunha, Wilson R. [1] ; Januario, Ana H. [1] ; Smilkstein, Martin J. [3, 4, 5] ; Riscoe, Michael K. [3, 4, 5, 6] ; Pauletti, Patricia M. [1]
Total Authors: 9
Affiliation:
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Dept Biol, Fac Filosofia Ciencias & Letras, Ribeirao Preto, SP - Brazil
[3] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 - USA
[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 - USA
[5] Oregon Hlth & Sci Univ, Dept Emergency Med, Portland, OR 97201 - USA
[6] VA Med Ctr, Portland, OR - USA
Total Affiliations: 6
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 1, p. 36-39, JAN-FEB 2019.
Web of Science Citations: 0
Abstract

The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 mu g/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 mu M to >100 mu M. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 mu M) and 2-methylcardol triene 4 (IC50 = 5.39 mu M) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered. (C) 2019 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. (AU)

FAPESP's process: 16/06260-2 - Integrative systematic studies in Neotropical families, with emphasis on Rutaceae, Asteraceae and Rubiaceae
Grantee:Milton Groppo Júnior
Support type: Regular Research Grants
FAPESP's process: 13/09280-6 - Phytochemistry study and evaluation of the cytotoxicity and lipoxygenase inhibitory activity from Cerrado plants
Grantee:Patricia Mendonça Pauletti
Support type: Regular Research Grants
FAPESP's process: 13/20280-8 - Development and validation of an analytical method, phytochemical study, schistosomicidal and cytotoxic activities evaluation of Anacardium occidentale l. (Anacardiaceae)
Grantee:Tavane Aparecida Alvarenga
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/10313-4 - Phytochemistry study and evaluation of the schistosomicidal, cytotoxicity and leishmanicidal activities from cerrado plants
Grantee:Patricia Mendonça Pauletti
Support type: BIOTA-FAPESP Program - Regular Research Grants