Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Author(s)

Gimenez, Valeria M. M. ^[1] ; Alvarenga, Tavane A. ^[1] ; Groppo, Milton ^[2] ; A e Silva, Marcio L. ^[1] ; Cunha, Wilson R. ^[1] ; Januario, Ana H. ^[1] ; Smilkstein, Martin J. ^{[3, 4, 5]} ; Riscoe, Michael K. ^{[3, 4, 5, 6]} ; Pauletti, Patricia M. ^[1]

Affiliation

^[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol, Fac Filosofia Ciencias & Letras, Ribeirao Preto, SP - Brazil

^[3] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 - USA

^[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 - USA

^[5] Oregon Hlth & Sci Univ, Dept Emergency Med, Portland, OR 97201 - USA

^[6] VA Med Ctr, Portland, OR - USA

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 1, p. 36-39, JAN-FEB 2019.
• Web of Science Citations: 0

Abstract

Abstract The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 µg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 µM to >100 µM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 µM) and 2-methylcardol triene 4 (IC50 = 5.39 µM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered. (AU)

• FAPESP's process: 13/09280-6 - Phytochemistry study and evaluation of the cytotoxicity and lipoxygenase inhibitory activity from Cerrado plants
• Grantee: Patricia Mendonça Pauletti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/06260-2 - Integrative systematic studies in Neotropical families, with emphasis on Rutaceae, Asteraceae and Rubiaceae
• Grantee: Milton Groppo Júnior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/10313-4 - Phytochemistry study and evaluation of the schistosomicidal, cytotoxicity and leishmanicidal activities from cerrado plants
• Grantee: Patricia Mendonça Pauletti
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 13/20280-8 - Development and validation of an analytical method, phytochemical study, schistosomicidal and cytotoxic activities evaluation of Anacardium occidentale L. (Anacardiaceae)
• Grantee: Tavane Aparecida Alvarenga
• Support Opportunities: Scholarships in Brazil - Master