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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zika Virus in Peridomestic Neotropical Primates, Northeast Brazil

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Author(s):
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Favoretto, Silvana R. [1, 2] ; Araujo, Danielle B. [1, 2] ; Duarte, Nayle F. H. [3] ; Oliveira, Danielle B. L. [1] ; da Crus, Nathalia G. [1] ; Mesquita, Flavio [1] ; Leal, Fabyano [1] ; Machado, Rafael R. G. [1] ; Gaio, Fernanda [4] ; Oliveira, Walber F. [4] ; Zanotto, Paolo M. A. [1] ; Durigon, Edison L. [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Lab Clin & Mol Virol, Ave Prof Lineu Prestes 1374, Room 225, BR-05508900 Sao Paulo, SP - Brazil
[2] Pasteur Inst Sao Paulo, Ave Paulista 393, BR-01311000 Sao Paulo, SP - Brazil
[3] Hlth Dept Ceara State NUVET SESA, Ctr Vector Borne Dis, Rua Tabajaras 268, BR-60060510 Fortaleza, Ceara - Brazil
[4] Brazilian Inst Environm & Renewable Nat Resources, Wild Anim Screening Ctr CETAS, Rua Wilson Pereira 351, BR-60843150 Fortaleza, Ceara - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ECOHEALTH; v. 16, n. 1, p. 61-69, MAR 2019.
Web of Science Citations: 4
Abstract

Zika virus (ZIKV) is a mosquito-borne viral disease associated with fetal microcephaly and other central nervous system (CNS) symptomatology. It was first identified in a Rhesus macaque in Uganda in 1947 and later in humans (Zika fever). In 2015, ZIKV was notified in Northeast Brazil where it was associated with CNS alterations and with rapid epidemic spread. Considering that ZIKV infects Old World monkeys, the aim of this study was to follow its potential in neotropical primates. Here, we show the detection of ZIKV in marmosets and capuchin monkeys captured in Ceara state, Northeast Brazil. Nine (9/132) samples were positive by quantitative RT-PCR assay. Neutralizing antibodies in primates for ZIKV were also detected by PRNT. The ZIKV-positive samples were obtained from peridomestic animals captured in proximity to humans in areas with reports of ZIKV-associated microcephaly cases during the epidemic period. These results reiterate the molecular evidence of ZIKV infection in neotropical primates, and the temporal detection suggests that detection in primates occurred during the epidemic period in humans. However, a continuous surveillance is necessary to exclude the possibility of virus circulation and transmission in wild environments. (AU)

FAPESP's process: 14/16333-1 - Rabies in terrestrial wild fauna from de Northeast region of Brazil: molecular epidemiology and detection of immune response
Grantee:Silvana Regina Favoretto
Support Opportunities: Regular Research Grants