Recent advances in indoline synthesis

Author(s)

Silva, Thiago S. ^[1] ; Rodrigues, Jr., Manoel T. ^[1] ; Santos, Hugo ^[1] ; Zeoly, Lucas A. ^[1] ; Almeida, Wanda P. ^[2] ; Barcelos, Rosimeire C. ^[3] ; Gomes, Ralph C. ^[1] ; Fernandes, Fabio S. ^[1] ; Coelho, Fernando ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, Lab Synth Nat Prod & Drugs, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Rua Candido Portinari 200, BR-13083971 Campinas, SP - Brazil

^[3] Inst Fed Ciencia Tecnol & Educ Minas Gerais, Belo Horizonte, MG - Brazil

• Document type: Journal article
• Source: Tetrahedron; v. 75, n. 14, p. 2063-2097, APR 5 2019.
• Web of Science Citations: 6

Abstract

Indoline is an important structural motif present in several biologically active compounds from both natural and synthetic origins. The occurrence of this heterocyclic unity in these compounds is closely related to the biological activities they exhibit. This fact stimulated efforts that have been made worldwide to develop new synthetic approaches to prepare indolines. In this paper we reviewed critically the methods for indoline synthesis developed in the last years (from 2010 to 2018). (C) 2019 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 15/09205-0 - New frontiers of the Morita-Baylis-Hillman reaction: 1) New applications of a bifunctional catalyst derived from imidazole. 2) Studies on the asymmetric synthesis of a natural high-potency sweetener
• Grantee: Hugo dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 18/02611-0 - Post-Functionalization of Small Ply-functionalized Molecules: A Robust Approach to the Synthesis of New Structural Patterns with POtential Biological Activity
• Grantee: Fernando Antonio Santos Coelho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/23005-6 - Synthesis of new heterocycles exhibiting potential biological activities by exploring the Morita-Baylis-Hillman adducts as building blocks
• Grantee: Fábio de Souza Fernandes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral