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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Distinct healing pattern of maxillary sinus augmentation using the vitroceramic Biosilicate (R): Study in rabbits

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Thompson, Francis Cazzeli [1] ; Matsumoto, Mariza Akemi [2] ; Biguetti, Claudia Cristina [3] ; Muniz Renno, Ana Claudia [4] ; Holgado, Leandro de Andrade [1] ; Santiago Junior, Joel Ferreira [1] ; Munerato, Marcelo Salles [1] ; Saraiva, Patricia Pinto [3]
Total Authors: 8
[1] Sagrado Coracao Univ USC, Oral Biol Postgrad Program, Rua Irma Arminda 10-50, BR-17011160 Bauru, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[3] Univ Oeste Paulista UNOESTE, Fac Med Jau, R Angelo Martins 498, BR-17203480 Jau, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista UNIFESP, Ave Ana Costa, 95, BR-11060001 Santos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 99, p. 726-734, JUN 2019.
Web of Science Citations: 0

Objectives: To follow healing process of augmented maxillary sinus in rabbits analyzing the histological pattern of bone tissue formation, along with the osteogenic activity and vascularization using a bioactive vitroceramic in comparison to deproteinized bovine bone associated or not with autogenous bone graft. Design: Forty five male adult New Zealand rabbits, 5 months of age, mean weight of 4 Kg, underwent bilateral sinus augmentation surgeries to be divided in five groups: G - (Control) particulate autogenous bone graft (AG), BO - deproteinized bovine bone, BO+G - deproteinized bovine bone + AG, BSi - vitroceramic, and BSi + G - vitroceramic + AG. After 15, 45 and 90 days, all animals were euthanized for specimen's removal to be analyzed under light microscopy, histomorphometry, and immunohistochemistry for Runx2 and VEGF labeling. Results: G, BO and BO + G groups healed uneventfully, allowing the formation of mature remodeling bone at day 90, regarding the association of AG with the biomaterial. On the other hand, BSi and BSi + G groups showed an important cellular reaction and granulation/fibrous tissue formation from the first to the last period of observation. Runx-2 and VEGF immunolabeling were coherent with this result. However, histomorphometry did not reveal significant differences considering new bone formation. Conclusions: Reconstructed maxillary sinuses using Biosilicate (R) permitted satisfactory new bone formation in comparison to the deproteinized bovine bone and AG. However, the presence of granulation/fibrous tissue and inflammatory cells associated to the degrading biomaterial indicate that further studies should be careful performed considering the immunological aspect of this new biomaterial. (AU)

FAPESP's process: 16/03762-7 - Macrophages phenotype identification during repair of bone defect's reconstructed with different biomaterials and their influence on healing process and on the quality of newly formed bone
Grantee:Mariza Akemi Matsumoto
Support type: Regular Research Grants