Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors

Author(s)

Fabio Augusto Ito ^[1] ; Kazuhiro Ito ^[2] ; Ricardo Della Coletta ^[3] ; Pablo Agustín Vargas ^[4] ; Márcio Ajudarte Lopes ^[5]

Affiliation

^[1] Londrina State University. Department of Pathology - Brasil

^[2] Londrina State University. Department of Pathology - Brasil

^[3] University of Campinas (UNICAMP). Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[4] University of Campinas (UNICAMP). Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[5] University of Campinas (UNICAMP). Piracicaba Dental School. Department of Oral Diagnosis - Brasil

• Document type: Journal article
• Source: Brazilian Oral Research; v. 23, n. 4, p. 393-398, 2009-12-00.

Abstract

The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies. (AU)