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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of systemic antibiotics administered during the active phase of non-surgical periodontal therapy or after the healing phase: a systematic review

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Author(s):
Aretuza FRITOLI [1] ; Cristiane GONÇALVES [2] ; Marcelo FAVERI [3] ; Luciene Cristina FIGUEIREDO [4] ; Paula Juliana PÉREZ-CHAPARRO [5] ; Daiane FERMIANO [6] ; Magda FERES [7]
Total Authors: 7
Affiliation:
[1] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[2] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[3] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[4] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[5] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[6] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
[7] Guarulhos University. Dental Research Division. Department of Periodontology - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Journal of Applied Oral Science; v. 23, n. 3, p. 249-254, 2015-06-00.
Abstract

Objective The aim of this systematic review was to compare the clinical effectiveness of systemic antibiotics administered in the active stage of periodontal treatment or after the healing phase. Material and Methods An electronic search was performed in the databases EMBASE, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL), in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. A manual search of the reference list of selected studies and of review articles was also performed up to November 2013. Randomized Clinical Trials (RCT) that evaluated the systemic administration of antibiotics as adjuvants to scaling and root planning (SRP) at different phases of periodontal treatment were included. Systematic reviews and studies that evaluated subjects with systemic diseases and those that used subantimicrobial doses of antibiotics were excluded. Results The initial search identified 1,039 articles, of which seven were selected, and only one met the inclusion criteria. This study showed that subjects taking metronidazole and amoxicillin at the initial phase of treatment exhibited statistically significantly greater reduction in pocket depth and gain in clinical attachment level in initially deep sites (PD≥7 mm) than subjects taking antibiotics after healing (p<0.05). This comparison was conducted 2 months after antibiotic intake, at the healing phase. Conclusion To date, only one short-term RCT has directly compared different moments of systemic antibiotics administration, as adjuncts to SRP, in the treatment of periodontitis. Although the results of this study suggested some benefits for antibiotics intake during the active phase of therapy, these findings need to be confirmed by larger placebo-controlled randomized clinical trials with longer follow-up periods. (AU)

FAPESP's process: 12/20915-0 - Metagenomic analysis of periodontal subgingival microbiota in subjects with and without periodontal disease
Grantee:Paula Juliana Perez Chaparro
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/23731-8 - Clinical and microbiological outcomes of timing of administration of systemic amoxicillin plus metronidazole associated with SRP in the treatment of subjcts with periodontitis.
Grantee:Daiane Fermiano Brunale
Support Opportunities: Scholarships in Brazil - Doctorate