| Full text | |
| Author(s): Show less - |
Lucas Macedo Batitucci AMBRÓSIO
[1]
;
Emanuel da Silva ROVAI
[2]
;
Bruno Nunes de FRANÇA
[3]
;
Danilo Andrés BALZARINI
[4]
;
Ieda Santos ABREU
[5]
;
Sheyla Batista Bologna LOPES
[6]
;
Thaís Borguezan NUNES
[7]
;
Silvia Vanessa LOURENÇO
[8]
;
Sandra Gofinet PASOTO
[9]
;
Luciana SARAIVA
[10]
;
Marinella HOLZHAUSEN
[11]
Total Authors: 11
|
| Affiliation: Show less - | [1] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[2] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[3] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[4] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[5] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[6] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[7] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[8] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[9] Universidade de São Paulo. School of Medicine - Brasil
[10] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
[11] Universidade de São Paulo. School of Dentistry. Department of Stomatology - Brasil
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | Brazilian Oral Research; v. 31, 2017-01-16. |
| Abstract | |
Abstract The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren’s Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1β, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients. (AU) | |
| FAPESP's process: | 15/07396-2 - Effect of protease activated receptor 1 (PAR1) activation on osteogenic activity of periodontal ligament cells |
| Grantee: | Marinella Holzhausen Caldeira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/26381-0 - Analysis of cytokines (in gingival fluid and serum) and periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) in patients with aggressive periodontitis. longitudinal study |
| Grantee: | Luciana Saraiva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/06387-7 - Expression of protease activated receptor 2 (PAR-2) in crevicular fluid cells of type 2-diabetic patients |
| Grantee: | Bruno Nunes de França |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |