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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Morphometric evaluation of NB84, synaptophysin and AgNOR is useful for the histological diagnosis and prognosis in peripheral neuroblastic tumors (pNTs)

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Author(s):
Aparecida de Cássia Carvalho [1] ; Edwin Roger Parra [2] ; Maria Cláudia Zerbini [3] ; Venâncio Avancini Ferreira Alves [4] ; Vera Luiza Capelozzi [5] ; Leila Antonangelo [6]
Total Authors: 6
Affiliation:
[1] University of São Paulo. School of Medicine. Department of Pathology - Brasil
[2] University of São Paulo. School of Medicine. Department of Pathology - Brasil
[3] University of São Paulo. School of Medicine. Clinical Hospital - Brasil
[4] Institute Adolfo Lutz. Department of Pathology - Brasil
[5] University of São Paulo. School of Medicine. Department of Pathology - Brasil
[6] University of São Paulo. School of Medicine. Department of Pathology - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Clinics; v. 62, n. 6, p. 731-740, 2007-00-00.
Abstract

OBJECTIVE: To study the importance of NB84, synaptophysin and AgNOR and explore the quantitative association of these factors with diagnosis and outcome as well as the association between NB84 and AgNOR and other tumor and stromal factors in twenty-eight peripheral neuroblastic tumors. METHODS: We assessed AgNORs, NB84, synaptophysin and several other markers in tumor tissues from 28 patients with primary neuroblastic tumors. The treatment included: surgery for stage 1, chemotherapy and bone marrow transplantation for most of stages 3 and 4. Histochemistry, immunohistochemistry and morphometry were used to evaluate the amount of tumor staining for AgNOR, NB84 and synaptophysin; the outcome for our study was survival time until death due to recurrent neuroblastic tumors. RESULTS: Only stage (p<0.01), AgNOR (p<0.01), NB84 (p<0.01) and synaptophysin (p=0.01) reached statistical significance as prognostic indicators. CONCLUSIONS: Determination of NB84 and synaptophysin are useful tools for the diagnosis of peripheral neuroblastic tumors The association of the evaluation of AgNOR expression by the tumor cells may provide an important contribution to the prognostic evaluation and management approach of the patients. (AU)

FAPESP's process: 00/14336-0 - Interstitial lung diseases (ILD): morphologic, functional and tomographic correlations using histochemistry, immunohistochemistry and morphometric techniques
Grantee:Vera Luiza Capelozzi
Support Opportunities: Research Projects - Thematic Grants