The influence of cigarette smoke inhalation on bone density: a radiographic study in rats

Author(s)

João Batista César-Neto ^[1] ; Bruno Braga Benatti ^[2] ; Flávio Ricardo Manzi ^[3] ; Enilson Antônio Sallum ^[4] ; Antônio Wilson Sallum ^[5] ; Francisco Humberto Nociti Junior ^[6]

Affiliation

^[1] State University of Campinas. School of Dentistry of Piracicaba. Division of Periodontics

^[2] State University of Campinas. School of Dentistry of Piracicaba. Division of Periodontics

^[3] State University of Campinas. School of Dentistry of Piracicaba. Division of Radiology

^[4] State University of Campinas. School of Dentistry of Piracicaba. Division of Periodontics

^[5] State University of Campinas. School of Dentistry of Piracicaba. Division of Periodontics

^[6] State University of Campinas. School of Dentistry of Piracicaba. Division of Periodontics

• Document type: Journal article
• Source: Brazilian Oral Research; v. 19, n. 1, p. 47-51, 2005-03-00.

Abstract

The aim of this study was to evaluate the influence of cigarette smoke inhalation (CSI) and its cessation on tibiae bone quality. Forty-one male Wistar rats were randomly assigned to one of the following groups: Group 1 - control (n = 14), Group 2 - 3 months of CSI and 2 months without exposure to CSI (n = 12), and Group 3 - 5 months of CSI (n = 15). At the end of the experimental period, the animals were sacrificed, the tibiae removed and immediately radiographed for photodensitometric analysis. The results showed that continuous exposure to cigarette smoke promoted a significantly reduced bone density (p < 0.05) (3.22 mm Al eq ± 0.58; 2.93 mm Al eq ± 0.45; 1.86 mm Al eq ± 0.35; for groups 1, 2 and 3, respectively). Similar levels of bone density were observed for the control and cessation groups (groups 1 and 2 - p > 0.05). Thus, within the limits of the present study, it can be concluded that CSI may affect tibiae bone quality, and CSI cessation results in a return towards the level of the control group. (AU)