Punicic acid was metabolised and incorporated in the form of conjugated linoleic acid in different rat tissues

Author(s)

Pereira de Melo, Illana Louise ^[1] ; de Oliveira e Silva, Ana Mara ^[2] ; Yoshime, Luciana Tedesco ^[1] ; Gasparotto Sattler, Jose Augusto ^[1] ; Teixeira de Carvalho, Eliane Bonifacio ^[1] ; Mancini-Filho, Jorge ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Lab Lipids, Ave Prof Lineu Prestes 580, Bloco 14, BR-05508900 Sao Paulo - Brazil

^[2] Univ Fed Sergipe, Biol Sci & Hlth Ctr, Aracaju, Sergipe - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION; v. 70, n. 4, p. 421-431, MAY 19 2019.
• Web of Science Citations: 1

Abstract

The objective of this study was to evaluate the effects of a supplementation of pomegranate seed oil (PSO), being rich in punicic acid, on the biochemical parameters of healthy rats. PSO was given to the animals intragastrically for 40 days at concentrations of 1%, 2% and 4%. There were no changes in their total body weight gain, their serum biochemical markers, or in the oxidative stress in their tissues. However, the TBARS values were reduced in the brains of the animals, noting that no significant amounts of conjugated fatty acids were found in this tissue. Conjugated linoleic acid (CLA) was present in all the other tissues studied. The results obtained have demonstrated that punicic acid from PSO was metabolised and incorporated in the form of CLA in different rat tissues. It did not cause alterations in their lipid metabolism, nor did it participate in the processes of oxidation inhibition. (AU)

• FAPESP's process: 09/51891-7 - Effect in rats of the isomers of conjugated linoleic acid (9cis, 11trans and 10trans, 12cis) and conjugated a-Iinolenic acid (9cis, 11trans, 13cis) on the tissue lipid profile and its effect on biochemical parameters in oxidative processes
• Grantee: Jorge Mancini Filho
• Support Opportunities: Regular Research Grants