Antibiotic resistance and heavy metal tolerance plasmids: the antimicrobial bulletproof properties of Escherichia fergusonii isolated from poultry

Author(s)

Galetti, Renata ^[1] ; Casarin Penha Filho, Rafael Antonio ^[2] ; Ferreira, Joseane Cristina ^[1] ; Varani, Alessandro M. ^[2] ; Costa Darini, Ana Liicia ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto - Brazil

^[2] Univ Estadual Paulista, Fac Ciencias Agr & Veterinarias, UNESP, Jaboticabal - Brazil

• Document type: Journal article
• Source: INFECTION AND DRUG RESISTANCE; v. 12, p. 1029-1033, 2019.
• Web of Science Citations: 1

Abstract

We describe the mobilome of Escherichia fergusonii 40A isolated from poultry, consisting of four different plasmids, p46\_40A (IncX1, 45,869 bp), p80\_40A (non-typable, 79,635 bp), p150\_40A (IncI1-ST1, 148,340 bp) and p280\_40A (IncHI2A-ST2, 279,537 bp). The mobilome-40A carries a blend of several different resistance and virulence genes, heavy metal tolerance operons and conjugation system. This mobilome 40A is a perfect tool to preserve and disseminate antimicrobial resistance and makes the bacterial isolate incredibly adapted to survive under constant antimicrobial pressure. (AU)

• FAPESP's process: 15/11728-0 - Complete sequencing of plasmids carrying antibiotic resistance genes in bacteria of interest and genome analysis of Pseudomonas aeruginosa-producing SPM-1 and KPC-2 lines by large-scale sequencing
• Grantee: Renata Galetti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/14494-8 - Molecular epidemiology of gram-negative bacteria and genetic of antibiotic resistance
• Grantee: Ana Lúcia da Costa Darini
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/12293-0 - Evaluation of the vaccine potential of recombinant proteins for protection against Salmonella enterica and the use of avian (Gallus gallus) cytokines as adjuvants and imunotherapics
• Grantee: Rafael Antonio Casarin Penha Filho
• Support Opportunities: Research Grants - Young Investigators Grants