Chemical composition and biological properties of Ipomoea procumbens

Author(s)

Batiga, Saadia ^[1] ; Valli, Marilia ^[2] ; Zeraik, Maria L. ^[3] ; Fraige, Karina ^[2] ; Leme, Gabriel M. ^[2] ; Pitangui, Nayla S. ^[4] ; Almeida, Ana Marisa F. ^[4] ; Michel, Sylvie ^[1] ; Young, Maria Claudia M. ^[5] ; Bolzani, Vanderlan S. ^[2]

Affiliation

^[1] Univ Paris 05, Lab Pharmacognosy, UMR CNRS Ctr Natl Rech Sci, Fac Pharm, Paris - France

^[2] Univ Estadual Paulista, Inst Quim, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Araraquara, SP - Brazil

^[3] Univ Estadual Londrina, Dept Quim, Londrina, PR - Brazil

^[4] Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, Lab Micol Clin, Araraquara, SP - Brazil

^[5] Secretaria Meio Ambiente Estado Sao Paulo, Inst Bot, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 2, p. 191-197, MAR-APR 2019.
• Web of Science Citations: 0

Abstract

ABSTRACT Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuable source of secondary metabolites that can be useful for the development of bioproducts. Ipomoea species, Convolvulaceae, are mostly found in tropical and sub-tropical regions, including South America and many are used for nutritional and medicinal purposes. Ipomoea procumbens Mart. & Choisy is endemic from South America, and this is the first study reported on the chemical composition and biological activities of this species. The present work reports the tentatively identification of natural products present in the extracts using a high performance liquid chromatography–high resolution mass spectrometry method. Additionally, the antioxidant and antifungal biological activities of the leaves, roots and steams extracts and fractions of this species were evaluated. While for the antioxidant activity the hydromethanol fractions (leaves, stem and roots) were more active, the methanol fractions of leaves and stem provided better results for the antifungal assay. (AU)

• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 10/17329-7 - NuBBE natural products, micromolecular diversity useful for the rational design of novel anticancer agents
• Grantee: Marilia Valli
• Support Opportunities: Scholarships in Brazil - Doctorate