| Full text | |
| Author(s): Show less - |
Okoshi, K.
[1, 2]
;
Cezar, M. D. M.
[1, 2, 3]
;
Polin, M. A. M.
[1, 2]
;
Paladino Jr, J. R.
;
Martinez, P. F.
[4]
;
Oliveira Jr, S. A.
;
Lima, A. R. R.
[5, 6]
;
Damatto, R. L.
[5, 6, 3]
;
Paiva, S. A. R.
[5, 6]
;
Zornoff, L. A. M.
[5, 6]
;
Okoshi, M. P.
[5, 6]
Total Authors: 11
|
| Affiliation: | [1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil
[2] UNESP, Fac Med Botucatu, Dept Clin Med, Rubiao Jr S-N, BR-18618687 Botucatu, SP - Brazil
[3] FAIT, Itapeva Social & Agrarian Sci Coll, Itapeva, SP - Brazil
[4] Univ Fed Mato Grosso do Sul, Cidade Univ, Av Costa & Silva Pioneiros, BR-79070900 Campo Grande, MS - Brazil
[5] Paladino Jr, Jr., J. R., Sao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil
[6] Paladino Jr, Jr., J. R., UNESP, Fac Med Botucatu, Dept Clin Med, Rubiao Jr S-N, BR-18618687 Botucatu, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | BMC CARDIOVASCULAR DISORDERS; v. 19, MAY 28 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
BackgroundInformation on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival.MethodsWistar rats were intermittently fasted (food available every other day) or fed ad libitum for 12weeks and then divided into three groups: AL - fed ad libitum; AL/IF - fed AL before MI and IF after MI; and IF - fed IF before and after MI. Echocardiogram was performed before MI and 2 and 12weeks after surgery. Isolated hearts were evaluated in Langendorff preparations.ResultsBefore surgery, body weight (BW) was lower in IF than AL. Final BW was lower in AL/IF and IF than AL. Perioperative mortality did not change between AL (31.3%) and IF (27.3%). Total mortality was lower in IF than AL. Before surgery, echocardiographic parameters did not differ between groups. Two weeks after surgery, MI size did not differ between groups. Twelve weeks after MI, left ventricular (LV) diastolic posterior wall thickness was lower in AL/IF and IF than AL. The percentage of variation of echocardiographic parameters between twelve and two weeks showed that MI size decreased in all groups and the reduction was higher in IF than AL/IF. In Langendorff preparations, LV volume at zero end-diastolic pressure (V0; AL: 0.410.05; AL/IF: 0.34 +/- 0.06; IF: 0.28 +/- 0.05mL) and at 25mmHg end-diastolic pressure (V25; AL: 0.61 +/- 0.05; AL/IF: 0.54 +/- 0.07; IF: 0.44 +/- 0.06mL) was lower in AL/IF and IF than AL and V25 was lower in IF than AL/IF. V0/BW ratio was lower in IF than AL and LV weight/V0 ratio was higher in IF than AL. Myocyte diameter was lower in AL/IF and IF than AL (AL: 17.3 +/- 1.70; AL/IF: 15.1 +/- 2.21; IF: 13.4 +/- 1.49m). Myocardial hydroxyproline concentration and gene expression of ANP, Serca 2a, and - and -myosin heavy chain did not differ between groups.ConclusionIntermittent fasting initiated before or after MI reduces myocyte hypertrophy and LV dilation. Myocardial fibrosis and fetal gene expression are not modulated by feeding regimens. Benefit is more evident when intermittent fasting is initiated before rather than after MI. (AU) | |