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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies

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Author(s):
Fernandes, Alessandra A. G. [1] ; da Silva, Amanda F. [1] ; Okada, Jr., Celso Y. [1] ; Suzukawa, Vitor [1] ; Cormanich, Rodrigo A. [1] ; Jurberg, Igor D. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, Rua Monteiro Lobato 270, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2019, n. 19, p. 3022-3034, MAY 26 2019.
Web of Science Citations: 0
Abstract

A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions. (AU)

FAPESP's process: 17/22164-6 - New transformations involving isoxazol-5-ones
Grantee:Alessandra Aparecida de Godoy Fernandes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/24017-0 - Application of Isoxazolones in Organic Synthesis
Grantee:Igor Dias Jurberg
Support Opportunities: Regular Research Grants
FAPESP's process: 18/03910-1 - Physicochemical studies of fluorinated organic compounds: experimental and theoretical approaches
Grantee:Rodrigo Antonio Cormanich
Support Opportunities: Research Grants - Young Investigators Grants