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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paracrine/autocrine control of spermatogenesis by gonadotropin-inhibitory hormone

Full text
Author(s):
Fallah, Hamideh P. [1] ; Tovo-Neto, Aldo [1, 2, 3] ; Yeung, Edward C. [1] ; Nobrega, Rafael H. [2] ; Habibi, Hamid R. [1]
Total Authors: 5
Affiliation:
[1] Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4 - Canada
[2] Sao Paulo State Univ, Dept Morphol, Reprod & Mol Biol Grp, Botucatu, SP - Brazil
[3] Sao Paulo State Univ Unesp, Aquaculture Program, Jaboticabal, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 492, JUL 15 2019.
Web of Science Citations: 1
Abstract

Control of testicular development is multifactorial and involves a number of hypothalamic, hypophyseal and peripheral hormones. Here, we investigated direct action of zebrafish gonadotropin-inhibitory hormone (zGnih) which is expressed in the testis, on spermatogenesis in zebrafish, in vitro. Treatment with zGnih at the lower doses (10 and 100 nM) inhibited gonadotropin-induced spermatids/spermatozoa (SPD/SPZ) production. However, at the highest dose (1000 nM), zGnih increased basal number of SPD/SPZ and showed paradoxical effect. The effects of zGnih on testosterone and SPD/SPZ production was blocked in the presence of androgen receptor antagonist, flutamide (FLU). A number of transcripts were also measured to better understand zGnih mechanisms of action on zebrafish spermatogenesis. Our results provide strong support for the hypothesis that locally produced zGnih is a component of the complex multifactorial system that regulates testicular development and function in adult zebrafish, in part, by changes in testicular steroidogenesis and regulation of gonadotropin-induced response. (AU)

FAPESP's process: 14/07620-7 - Spermatogonial stem cell bank to preserve the genotype of endangered and valuable teleost species
Grantee:Rafael Henrique Nóbrega
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/09218-0 - Effects of methimazole-induced thyroid hormone insufficiency on zebrafish (Danio rerio) spermatogenesis
Grantee:Aldo Tovo Neto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/16280-5 - Molecular and endocrine control involved on gonadal differentiation of zebrafish (Danio rerio)
Grantee:Aldo Tovo Neto
Support Opportunities: Scholarships in Brazil - Doctorate