| Full text | |
| Author(s): Show less - |
dos Santos, Marcio G.
[1]
;
Moreno, Felipe S.
[2]
;
de Oliveira, Akila L.
[2]
;
Oliveira, Isadora C. F.
[2]
;
Tribuiani, Natalia
[3]
;
Cogo, Jose C.
[4]
;
Scriboni, Andreia B.
[5]
;
Cogo-Mueller, Karina
[6, 5]
;
San Feliciano, Arturo
[7]
;
Bonomini, Tiago Jose
[8]
;
Fernandes, Joao B.
[9]
;
Oshima-Franco, Yoko
[2, 3]
Total Authors: 12
|
| Affiliation: | [1] Tocantins Fed Univ UFT, Environm Sci Postgrad Program PGCiamb, Palmas - Brazil
[2] Univ Sorocaba UNISO, Vet Med Grad Course, Sorocaba - Brazil
[3] Univ Sorocaba UNISO, Postgrad Program Pharmaceut Sci, Sorocaba - Brazil
[4] Univ Brasil, Biomed Engn & Bioengn, Sao Paulo - Brazil
[5] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Pharmacol, Piracicaba - Brazil
[6] Univ Campinas Unicamp, Fac Pharmaceut Sci, Campinas, SP - Brazil
[7] Salamanca Univ USAL, Fac Pharm, Dept Pharmaceut Chem, Campus Miguel de Unamuno, Salamanca - Spain
[8] Univ Vale Itajai UNIVALI, Programa Posgrad Ciencias Farmaceut, Nucleo Invest Quim Farmaceut NIQFAR, Itajai, SC - Brazil
[9] Fed Univ Sao Carlos UFSCar, Dept Chem, Sao Carlos, SP - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT RESEARCH; v. 33, n. 16, p. 2389-2393, AUG 18 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. Additionally, the antimicrobial potential of HEGg was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains, as well as Rutin was isolated for the first time in this specie using chromatographic and spectroscopic methods and its antiophidian property was assessed. HEGg totally prevents the neurotoxicity and myotoxicity effects caused by B. jararacussu, but did not show any antimicrobial effect. Concluding, HEGg and Rutin were able to counteract the toxic effects of the venom and confirmed the antiophidian potential, but not antimicrobial, of G. glaucescens as an alternative for neutralization of B. jararacussu venom. {[}GRAPHICS] . (AU) | |
| FAPESP's process: | 14/26786-3 - Neutralizing ability of hydroalcoholic extract and two isolated phytochemicals (A and B) from Galactia glauscescens against the in vitro neuromuscular blockade-induced by Bothrops jararacussu venom |
| Grantee: | Felipe Silveira Moreno |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 15/01420-9 - Development and efficacy evaluation (in vitro and in vivo) of a hemoperfuser cartridge for the antiophidian treatment |
| Grantee: | Yoko Oshima Franco |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/08271-0 - IDENTIFICATION AND PHARMACODYNAMIC OF NEUROFACILITATING FRACTIONS OF Casearia sylvestris SW. AT THE NEUROMUSCULAR JUNCTION |
| Grantee: | Yoko Oshima Franco |
| Support Opportunities: | Regular Research Grants |