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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Comparative Study on Chemical Composition, Antileishmanial and Cytotoxic Activities of the Essential Oils from Leaves of Guarea macrophylla (Meliaceae) from Two Different Regions of Sao Paulo State, Brazil, Using Multivariate Statistical Analysis

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Oliveira, Emerson A. [1] ; Martins, Euder G. A. [2] ; Soares, Marisi G. [3] ; Chagas-Paula, Daniela A. [3] ; Passero, Luiz F. D. [4, 5] ; Sartorelli, Patricia [1] ; Baldim, Joao L. [6] ; Lago, Joao Henrique G. [6]
Total Authors: 8
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
[2] Univ Sao Paulo, Inst Biociencias, BR-05508090 Sao Paulo, SP - Brazil
[3] Univ Fed Alfenas, Inst Quim, BR-37130001 Alfenas, MG - Brazil
[4] Univ Estadual Paulista, Inst Biociencias, BR-11330900 Sao Vicente, SP - Brazil
[5] Univ Estadual Paulista, Inst Estudos Avancados Mar, BR-11330900 Sao Vicente, SP - Brazil
[6] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 30, n. 7, p. 1395-1405, JUL 2019.
Web of Science Citations: 0

Meliaceae representatives are economically important in several aspects including the production of highly prized woods (mahogany, cedar, etc.), constituents for cosmetics, and insecticides. The present study aimed to verify the chemical composition as well as leishmanicidal and cytotoxic potential of essential oils from leaves of two different populations of Guarea macrophylla collected at cities of Sao Paulo (population I) and Cubatao (population II), Sao Paulo State, Brazil. Chemically, the oils showed the predominance of sesquiterpenes: cis-beta-guaiene, bicyclogermacrene, viridiflorol, and isolongifolan-7 alpha-ol from population I and alpha-copaene, E-caryophyllene, cis-beta-guaiene, and gamma-amorphene from population II. In vitro antileishmanial activity against promastigote forms of Leishmania (L.) amazonensis of essential oils was evaluated and displayed 50% effective concentration (EC50) values ranging from 11.8 to 20.5 mu g mL(-1). Furthermore, toxicity against peritoneal macrophages of BALB/c mice was observed, with 50% cytotoxic concentration (CC50) ranging from 17.7 to > 100 mu g mL(-1). Multivariate statistical analysis revealed the influence of each constituent of the oils against L. amazonensis being 1,10-di-epi-cubenol, alpha-amorphene, E-caryophyllene, isopimara-7,15-diene, and beta-elemene associated with the antileishmanial potential. (AU)

FAPESP's process: 16/19269-8 - Metabolic induction guided by genomic-mining strategies in Burkholderia thailandensis for the biosynthesis of antibiotic-like natural products
Grantee:Joao Luiz Baldim Zanin
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 16/00468-0 - Use of drug repurposing and natural product bioprospection to characterize compounds with in vitro and in vivo leishmanicidal action
Grantee:Luiz Felipe Domingues Passero
Support type: Regular Research Grants