Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II

Author(s):Show less -

Machado de Rezende, Leandro Fornias ^{[1, 2]} ; Lee, Dong Hoon ^[2] ; Keum, NaNa ^{[2, 3]} ; Nimptsch, Katharina ^{[2, 4]} ; Song, Mingyang ^{[5, 6, 7, 8, 2]} ; Lee, I-Min ^{[5, 9]} ; Eluf-Neto, Jose ^[1] ; Ogino, Shuji ^{[10, 5, 6, 11]} ; Fuchs, Charles ^{[12, 13, 14]} ; Meyerhardt, Jeffrey ^[15] ; Chan, Andrew T. ^{[10, 6, 16, 7, 8, 17]} ; Willett, Walter ^{[5, 6, 16, 2]} ; Giovannucci, Edward ^{[5, 6, 16, 2]} ; Wu, Kana ^[2]

Affiliation:Show less -

^[1] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil

^[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA

^[3] Dongguk Univ, Dept Food Sci & Biotechnol, Goyang - South Korea

^[4] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Res Grp, Berlin - Germany

^[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA

^[6] Harvard Med Sch, Boston, MA 02115 - USA

^[7] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 - USA

^[8] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 - USA

^[9] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 - USA

^[10] Broad Inst MIT & Harvard, Cambridge, MA 02142 - USA

^[11] Brigham & Womens Hosp, Dept Pathol, Program MPE Mol Pathol Epidemiol, 75 Francis St, Boston, MA 02115 - USA

^[12] Yale Canc Ctr, New Haven, CT - USA

^[13] Yale Sch Med, Dept Med, New Haven, CT - USA

^[14] Smilow Canc Hosp, New Haven, CT - USA

^[15] Dana Faber Canc Inst, Boston, MA - USA

^[16] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA

^[17] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA - USA

• Document type: Journal article
• Source: BRITISH JOURNAL OF CANCER; v. 121, n. 1, p. 86-94, JUL 2 2019.
• Web of Science Citations: 0

Abstract

BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12-22 years) in 1997 and underwent lower bowel endoscopy (1998-2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77-1.02; P-trend = 0.03) comparing women with >= 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (>= 53.3 MET-h/week) and adulthood (>= 23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66-0.88; advanced adenoma: OR 0.61; 95% CI 0.45-0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life. (AU)

• FAPESP's process: 16/21390-0 - Burden of cancer attributable to lifestyle risk factors in Brazil
• Grantee: Leandro Fórnias Machado de Rezende
• Support type: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact
• Grantee: Leandro Fórnias Machado de Rezende
• Support type: Scholarships in Brazil - Doctorate