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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II

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Author(s):
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Machado de Rezende, Leandro Fornias [1, 2] ; Lee, Dong Hoon [2] ; Keum, NaNa [2, 3] ; Nimptsch, Katharina [2, 4] ; Song, Mingyang [5, 6, 7, 8, 2] ; Lee, I-Min [5, 9] ; Eluf-Neto, Jose [1] ; Ogino, Shuji [10, 5, 6, 11] ; Fuchs, Charles [12, 13, 14] ; Meyerhardt, Jeffrey [15] ; Chan, Andrew T. [10, 6, 16, 7, 8, 17] ; Willett, Walter [5, 6, 16, 2] ; Giovannucci, Edward [5, 6, 16, 2] ; Wu, Kana [2]
Total Authors: 14
Affiliation:
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[1] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA
[3] Dongguk Univ, Dept Food Sci & Biotechnol, Goyang - South Korea
[4] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Res Grp, Berlin - Germany
[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[6] Harvard Med Sch, Boston, MA 02115 - USA
[7] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 - USA
[8] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 - USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 - USA
[10] Broad Inst MIT & Harvard, Cambridge, MA 02142 - USA
[11] Brigham & Womens Hosp, Dept Pathol, Program MPE Mol Pathol Epidemiol, 75 Francis St, Boston, MA 02115 - USA
[12] Yale Canc Ctr, New Haven, CT - USA
[13] Yale Sch Med, Dept Med, New Haven, CT - USA
[14] Smilow Canc Hosp, New Haven, CT - USA
[15] Dana Faber Canc Inst, Boston, MA - USA
[16] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
[17] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA - USA
Total Affiliations: 17
Document type: Journal article
Source: BRITISH JOURNAL OF CANCER; v. 121, n. 1, p. 86-94, JUL 2 2019.
Web of Science Citations: 0
Abstract

BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12-22 years) in 1997 and underwent lower bowel endoscopy (1998-2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77-1.02; P-trend = 0.03) comparing women with >= 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (>= 53.3 MET-h/week) and adulthood (>= 23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66-0.88; advanced adenoma: OR 0.61; 95% CI 0.45-0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life. (AU)

FAPESP's process: 16/21390-0 - Burden of cancer attributable to lifestyle risk factors in Brazil
Grantee:Leandro Fórnias Machado de Rezende
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact
Grantee:Leandro Fórnias Machado de Rezende
Support type: Scholarships in Brazil - Doctorate