| Full text | |
| Author(s): Show less - |
Grandinetti, Vanessa
[1]
;
Carlos, Fernando P. Ereira
[1]
;
Antonio, Ednei Luiz
[2]
;
de Oliveira, Helenita Antonia
[2]
;
Neves dos Santos, Luis Felipe
[2]
;
Yoshizaki, Amanda
[2]
;
Dias Martins Mansano, Barbara Sampaio
[1]
;
Silva, Flavio Andre
[2, 3]
;
Porte, Leslie Andrews
[2, 3]
;
Albuquerque-Pontes, Gianna Moes
[1]
;
Camillo de Carvalho, Paulo de Tarso
[1]
;
Manchini, Martha Trindade
[1, 2]
;
Leal-Junior, Ernesto Cesar
[1]
;
Ferreira Tucci, Paulo Jose
[2]
;
Serra, Andrey Jorge
[1, 2]
Total Authors: 15
|
| Affiliation: | [1] Univ Nove Julho, Programa Posgrad Biofoton Aplicada Ciencias Saude, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Programa Posgrad Cardiol, Sao Paulo - Brazil
[3] Univ Adventista Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 9, JUL 1 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
The post-myocardial infarction heart failure (HF) still carries a huge burden since current therapy is unsuccessful to abrogate poor prognosis. Thus, new approaches are needed, and photobiomodulation therapy (PBMt) may be a way. However, it is not known whether PBMt added to a standard HF therapy provides additional improvement in cardiac remodeling in infarcted rats. This study sought to determine the combined carvedilol-drug and PBMt with low-level laser therapy value in HF. Rats with large infarcts were treated for 30 days. The functional fitness was evaluated using a motorized treadmill. Echocardiography and hemodynamic measurements were used for functional evaluations of left ventricular (LV). ELISA, Western blot and biochemical assays were used to evaluate inflammation and oxidative stress in the myocardium. Carvedilol and PBMt had a similar action in normalizing pulmonary congestion and LV end-diastolic pressure, attenuating LV dilation, and improving LV systolic function. Moreover, the application of PBMt to carvedilol-treated rats inhibited myocardial hypertrophy and improved +dP/dt of LV. PBMt alone prevented inflammation with a superior effect than carvedilol. Carvedilol and PBMt normalized 4-hydroxynonenal (a lipoperoxidation marker) levels in the myocardium. However, importantly, the addition of PBMt to carvedilol attenuated oxidized protein content and triggered a high activity of the anti-oxidant catalase enzyme. In conclusion, these data show that the use of PBMt plus carvedilol therapy results in a significant additional improvement in HF in a rat model of myocardial infarction. These beneficial effects were observed to be due, at least in part, to decreased myocardial inflammation and oxidative stress. (AU) | |
| FAPESP's process: | 18/06865-7 - Photobiomodulation with light-emitting diode (LED) can improve the efficiency of mesenquimial stem cell therapy in post-ischemic heart failure? |
| Grantee: | Andrey Jorge Serra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/11028-9 - The aerobic training method can determine the existence of cardiac remodeling: structural, functional and molecular analyzes of swimming and running experimental models. |
| Grantee: | Andrey Jorge Serra |
| Support Opportunities: | Regular Research Grants |