| Full text | |
| Author(s): |
Rodrigues-Junior, Dorival Mendes
[1]
;
Biassi, Thais Priscila
[1]
;
De Albuquerque, Gabriela Estrela
[1]
;
Carlin, Viviane
[1]
;
Buri, Marcus Vinicius
[2]
;
Machado-Junior, Joel
[1]
;
Vettore, Andre Luiz
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Fed Sao Paulo, UNIFESP, Lab Biol Mol Canc, Dept Biol Sci, Campus Diadema, Rua Pedro Toledo, 669-11 Andar, BR-04039032 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Insitute Pharmacol, Dept Biochem, Campus Sao Paulo, BR-04044020 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | MOLECULAR MEDICINE REPORTS; v. 19, n. 6, p. 5023-5029, JUN 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Multiple myeloma (MM) is an incurable disease; a better understanding of the molecular aspects of this hematological malignancy could contribute to the development of new treatment strategies and help to improve the survival rates of patients with MM. Previously, the methylation status of the deleted in colorectal cancer (DCC) gene was correlated with the survival rate of patients with MM, thus the main goal of this study was to understand DCC contribution to MM tumorigenesis, and to assess the impact of DCC inhibition in the MM response to treatment with bortezomib. Our results demonstrated that hypermethylation of the DCC promoter inhibits gene expression, and DCC silencing is significantly correlated with a reduction in cell viability and an increase in cell death induced by bortezomib. In conclusion, our results suggested that hypermethylation is an important mechanism of DCC expression regulation in MM and that the absence of DCC contributes to the enhanced sensitivity to treatment with bortezomib. (AU) | |
| FAPESP's process: | 12/01597-8 - FUNCTIONAL STUDY OF DCC AND TGFBR2 GENES IN MULTIPLE MYELOMA CELL LINES |
| Grantee: | Dorival Mendes Rodrigues Junior |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/14837-7 - Evaluation of the expression profile of microRNAs as diagnostic markers for cervical metastasis in patients with head and neck squamous cell carcinoma |
| Grantee: | André Lopes Carvalho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/20218-2 - Identification of cancer-testis antigens expressed in glioblastomas |
| Grantee: | Karina Ramalho Bortoluci |
| Support Opportunities: | Regular Research Grants |