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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study

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Author(s):
Fernandes Filgueira, Fabricia Geovania [1] ; Minto, Bruno Watanabe [2] ; Chung, Denise Granato [2] ; Prada, Tiago Carmagni [2] ; Rosa-Ballaben, Natalie Massaro [2] ; Nogueira Campos, Maria Gabriela [3]
Total Authors: 6
Affiliation:
[1] Sci & Technol Paraiba, Fed Inst Educ, Vet Hosp Adilio Santos de Azevedo, Sousa, Paraiba - Brazil
[2] Univ Estadual Paulista, Sch Agr & Vet Sci, Dept Vet Clin & Surg, Jaboticabal, SP - Brazil
[3] Univ Fed Alfenas, Inst Sci & Technol, Campus Pocos Caldas, Alfenas, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: VETERINARNI MEDICINA; v. 64, n. 7, p. 309-316, 2019.
Web of Science Citations: 0
Abstract

The goal of this study was to analyse the effects of percutaneous application of platelet rich plasma (PRP), autologous bone marrow concentrate (BM) and chitosan gel (CHI) on bone consolidation following minimally invasive plate osteosynthesis (MIPO) of the fractures of the tibia in dogs. Client-owned dogs (n = 30) with tibial fracture were divided into four treatment groups - Group 1 (control), Group 2 (BM), Group 3 (PRP) and Group 4 (CHI). The biomaterial specific to each group was injected at the fracture site immediately after the MIPO procedure. Serial radiographs were used to determine the fracture line and the development of periosteal callus immediately after surgery and at 15, 30, 60, 90 and 120 days post-surgery. There was no significant difference (P > 0.05) in the degree of oedema or grade of lameness between the groups. Grade 4 (minimum) or 5 lameness (absent) was observed in 70% of animals from all groups at 15 days post-surgery. The biomaterials PRP, BM and CHI combined with MIPO contribute to bone consolidation of tibial fractures in dogs and do not cause adverse reactions or fracture complications. Bone marrow concentrate results in shorter bone consolidation time. (AU)

FAPESP's process: 12/20642-4 - Platelet rich plasma and bone marrow in minimally invasive osteosynthesis of tibia in dogs
Grantee:Bruno Watanabe Minto
Support Opportunities: Regular Research Grants
FAPESP's process: 12/16712-7 - Platelet-rich plasma, bone marrow and chitosan in minimally invasive osteosynthesis of tibia in dogs
Grantee:Fabrícia Geovânia Fernandes Filgueira
Support Opportunities: Scholarships in Brazil - Doctorate