Thermally Modified Iron-Inserted Calcium Phosphate for Magnetic Hyperthermia in an Acceptable Alternating Magnetic Field

Author(s)

Srinivasan, Baskar ^[1] ; Kolanthai, Elayarap ^[2] ; Kumaraswamy, Nivethaa Eluppai Asthagiri ^[1] ; Jayapalan, Ramana Ramya ^[3] ; Vavilapalli, Durga Sankar ^[1] ; Catalani, Luiz Henrique ^[2] ; Ningombam, Goutam Singh ^[4] ; Khundrakpam, Nehru Singh ^[4] ; Singh, Nongmaithem Rajmuhon ^[4] ; Kalkura, Subbaraya Narayana ^[1]

Affiliation

^[1] Anna Univ, Crystal Growth Ctr, Chennai 600025, Tamil Nadu - India

^[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 784, BR-05508000 Sao Paulo - Brazil

^[3] Univ Madras, Natl Ctr Nanosci & Nanotechnol, Chennai 600 025, Tamil Nadu - India

^[4] Manipur Univ, Dept Chem, Imphal 795003, Manipur - India

• Document type: Journal article
• Source: Journal of Physical Chemistry B; v. 123, n. 26, p. 5506-5513, JUL 4 2019.
• Web of Science Citations: 0

Abstract

Magnetic hyperthermia treatment using calcium phosphate nanoparticles is an evolutionary choice because of its excellent biocompatibility. In the present work, Fe3+ is incorporated into HAp nanoparticles by thermal treatment at various temperatures. Induction heating was examined within the threshold Hf value of 4.58 X 10(6) kA m(-1) s(-1) (H is the strength of alternating magnetic field and f is the operating frequency) and sample concentration of 10 mg/mL. The temperature-dependent structural modifications are well correlated with the morphological, surface charge, and magnetic properties. Surface charge changes from +10 mV to -11 mV upon sintering because of the diffusion of iron in the HAp lattice. The saturation magnetization has been achieved by sintering the nanoparticles at 400 and 600 degrees C, which has led to the specific absorption rate of 12.2 and 37.2 W/g, respectively. Achievement of the hyperthermia temperature (42 degrees C) within 4 min is significant when compared with the existing magnetic calcium phosphate nanoparticles. The systematic investigation reveals that the HAp nanoparticles partially stabilized with FeOOH and biocompatible alpha-Fe2O3 exhibit excellent induction heating. In vitro tests confirmed the samples are highly hemocompatible. The importance of the present work lies in HAp nanoparticles exhibiting induction heating without compromising the factors such as Hf value, low sample concentration, and reduced duration of applied field. (AU)

• FAPESP's process: 15/19694-8 - Bioactivity of multi-layer membranes loaded with various protein markers for tissue engineering applications
• Grantee: Elayaraja Kolanthai
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/21442-6 - Synthetic and natural polymers applied to tissue engineering
• Grantee: Luiz Henrique Catalani
• Support Opportunities: Research Projects - Thematic Grants