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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil

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Author(s):
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da Silva, Alison B. [1] ; Silveira, Edilberto R. [1] ; Wilke, Diego V. [2] ; Ferreira, Elhton G. [2] ; Costa-Lotufo, Leticia V. [3] ; Torres, Maria Conceicao M. [1] ; Ayala, Alejandro Pedro [4] ; Costa, Wendell S. [5] ; Canuto, Kirley M. [6] ; de Araujo-Nobre, Alyne R. [7] ; Araujo, Ana Jersia [7] ; Marinho Filho, Jose Delano B. [7] ; Pessoa, Otilia Deusdenia L. [1]
Total Authors: 13
Affiliation:
[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, CE - Brazil
[2] Univ Fed Ceara, Nucleo Pesquisa & Desenvolvimento Medicamentos, BR-60430275 Fortaleza, CE - Brazil
[3] Univ Sao Paulo, Dept Farmacol, BR-05508900 Sao Paulo, SP - Brazil
[4] Univ Fed Ceara, Dept Fis, BR-60440970 Fortaleza, CE - Brazil
[5] Univ Fed Ceara, Dept Farm, BR-60430170 Fortaleza, CE - Brazil
[6] Embrapa Agroind Trop, BR-60511110 Fortaleza, CE - Brazil
[7] Univ Fed Piaui, Nucleo Pesquisa Biodiversidade & Biotecnol, BR-64202020 Parnaiba, PI - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Journal of Natural Products; v. 82, n. 7, p. 1831-1838, JUL 2019.
Web of Science Citations: 4
Abstract

Salinaphthoquinones A-E (1-5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds were elucidated using a combination of spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1-5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 125 to 16 mu g/mL. (AU)

FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants