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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63

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Author(s):
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Gubiani, Juliana R. [1] ; Oliveira, Michele C. S. [2] ; Neponuceno, Ricardo A. R. [3] ; Camargo, Maria J. [4] ; Garcez, Walmir S. [5] ; Biz, Andressa R. [6] ; Soares, Marcos A. [6] ; Araujo, Angela R. [7] ; Bolzani, Vanderlan da S. [7] ; Lisboa, Helen C. F. [8] ; de Sousa Jr, Paulo T. ; de Vasconcelos, Leonardo G. [9] ; Ribeiro, Tereza A. N. [9] ; de Oliveira, Juliana M. [10] ; Banzato, Thais P. [11] ; Lima, Carolina A. [12] ; Longato, Giovanna B. [12] ; Batista Jr, Joao M. ; Berlinck, Roberto G. S. [1] ; Teles, Helder L. [3]
Total Authors: 20
Affiliation:
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[1] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Mato Grosso, Dept Quim, Inst Ciencias Exatas & Terra, BR-78060900 Cuiaba, MT - Brazil
[3] Univ Fed Mato Grosso, Dept Biol, Inst Ciencias Exatas & Nat, Campus Rondonopolis, BR-78735901 Rondonopolis, MT - Brazil
[4] Inst Fed Mato Grosso, BR-78721520 Rondonopolis, MT - Brazil
[5] Univ Fed Mato Grosso do Sul, Inst Quim, BR-79070900 Campo Grande, MS - Brazil
[6] Univ Fed Mato Grosso, Inst Biociencias, BR-78060900 Cuiaba, MT - Brazil
[7] Univ Estadual Paulista, Inst Quim, Nuleo Bioensaios Biossintese & Ecofisiol Prod Nat, Dept Quim Organ, BR-14800900 Araraquara, SP - Brazil
[8] Univ Fed Mato Grosso, Dept Enfermagem, Campus Rondonopolis, BR-78735901 Rondonopolis, MT - Brazil
[9] de Sousa Jr, Jr., Paulo T., Univ Fed Mato Grosso, Dept Quim, Inst Ciencias Exatas & Terra, BR-78060900 Cuiaba, MT - Brazil
[10] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[11] Univ Estadual Campinas, Inst Biol, Dept Biol Func & Estrutural, BR-13083865 Campinas, SP - Brazil
[12] Univ Sao Francisco, Lab Pesquisa Biol Celular & Mol Tumores & Compost, BR-12916900 Braganca Paulista, SP - Brazil
Total Affiliations: 12
Document type: Journal article
Source: PHYTOCHEMISTRY LETTERS; v. 32, p. 162-167, AUG 2019.
Web of Science Citations: 0
Abstract

Prenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 14/25222-9 - Vibrational chiroptical spectroscopy for stereochemical characterization of small molecules and macromolecules
Grantee:João Marcos Batista Junior
Support Opportunities: Research Grants - Young Investigators Grants