Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bacterial viability after antimicrobial photodynamic therapy with curcumin on multiresistant Staphylococcus aureus

Full text
Author(s):
Freitas, Mirian A. A. [1] ; Pereira, Andre H. C. [1] ; Pinto, Juliana G. [1] ; Casas, Adriana [2] ; Ferreira-Strixino, Juliana [1]
Total Authors: 5
Affiliation:
[1] Univ Vale Paraiba, R&DI, Photodynam Therapy Lab, Univap, Shishima Hifumi Ave 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Buenos Aires, CONICET, Htal Clin Gral Jose de San Martin, CIPYP, Buenos Aires, DF - Argentina
Total Affiliations: 2
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 14, n. 9, p. 739-748, JUL 4 2019.
Web of Science Citations: 3
Abstract

Staphylococcus aureus are multiresistant pathogens that causes superficial and systemic infections. Antimicrobial photodynamic therapy (APDT) is an alternative in the treatment of diseases caused by these bacteria. Aim: In this study the APDT response on growth, viability, formation of reactive oxygen species and adhesion of methicillin-sensitive strains of Staphylococcus aureus, strains of methicillin-resistant S. aureusand American-type culture collection (ATCC) of S. aureus were evaluated in vitro, after incubation with curcumin for 20min, and irradiated with LED. Materials \& methods: Bacterial growth was assessed by the number of colony-forming units, viability and adhesion were evaluated by confocal microscopy and ROS quantification was performed by fluorimetry. Results: Was observed increase in the production of ROS in APDT groups, besides a decrease in the 4 log growth and loss of the bacterial adhesion. Conclusion: APDT with Curcumin may be an interesting therapeutic alternative, due to its in vitro response, in the control multiresistant clinical S. aureus strains. (AU)

FAPESP's process: 16/12211-4 - Study of the genotoxic effect, the membrane potential and cell death pathways of curcumin in photodynamic therapy in promastigote and amastigote forms of L. major and L. braziliensis: in vitro
Grantee:Juliana Ferreira Strixino
Support Opportunities: Regular Research Grants