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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of subcutaneous injection of ozone during wound healing in rats

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Author(s):
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Soares, Ciro D. [1] ; Morais, Thayna M. L. [1] ; Araujo, Roberta M. F. G. [2] ; Meyer, Patricia F. [3] ; Oliveira, Eric A. F. [3] ; Silva, V, Rodrigo M. ; Carreiro, Eneida M. [4] ; Carreiro, Edvaldo P. [4] ; Belloco, Veronica G. [5] ; Mariz, Bruno A. L. A. [1] ; Jorge-Junior, Jacks [1]
Total Authors: 11
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Oral Pathol Sect, Dept Oral Diag, Av Limeira 901, POB 52, BR-1314903 Piracicaba, SP - Brazil
[2] Univ Potiguar, Med Dept, Natal, RN - Brazil
[3] Univ Potiguar, Physiotherapy Dept, Natal, RN - Brazil
[4] Univ Ctr Rio Grande do Norte, Physiotherapy Dept, Natal, RN - Brazil
[5] FisioKine Ctr, Physiotherapy Dept, Buenos Aires, DF - Argentina
Total Affiliations: 5
Document type: Journal article
Source: GROWTH FACTORS; v. 37, n. 1-2 JULY 2019.
Web of Science Citations: 0
Abstract

Fibroblast growth factor 2 (FGF2) regulates the wound repair process and it is secreted by inflammatory and endothelial cells, and by myofibroblasts. This study aimed to establish the expression patterns of FGF2 and myofibroblastic differentiation during wound healing in rats treated with subcutaneous ozone injection. We created full-thickness excisional wounds in rats, and the healing process was analyzed through morphometric analyses and digital quantification of immunoreactivity of smooth muscle actin and FGF2. Ozone therapy-treated wounds presented granulation tissue with a reduced number of inflammatory cells and greater dermal cellularity, and intense collagen deposition. FGF2 immunoreactivity, microvessel density, and amount of myofibroblasts were significantly higher in treated wounds compared to controls. In conclusion, it was demonstrated that subcutaneous injections of ozone accelerate and ameliorate wound repairing process. Moreover, injectable ozone therapy's action mechanism may be associated with FGF2 overexpression. (AU)

FAPESP's process: 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas
Grantee:Jacks Jorge Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
Grantee:Ciro Dantas Soares
Support Opportunities: Scholarships in Brazil - Doctorate