Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case

Author(s)

Etrusco Zaroni Santos, Ana Carolina ^[1] ; Luglio, Michele ^[1] ; Delgado, Artur Figueiredo ^[1] ; Santo Vieira Schuwartz, Constance Dell ^[2] ; Sousa Marques, Heloisa Helena ^[2] ; de Miranda Valoes, Clarissa Carvalho ^[3] ; Cabrera Dominguez, Maria Andreina ^[1] ; de Carvalho, Werther Brunow ^[1] ; Silva, Clovis Artur ^[3] ; Duarte-Neto, Amaro Nunes ^[4]

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Inst Crianca, Unidade Terapia Intens Pediat, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Hosp Clin, Inst Crianca, Dept Infectol Pediat, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Hosp Clin, Inst Crianca, Dept Reumatol Pediat, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Hosp Clin, Dept Patol, Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 61, 2019.
• Web of Science Citations: 0

Abstract

ABSTRACT Acute petrified myocardium associated with septic shock, diagnosed by autopsy has rarely been described. A 15-year-old adolescent male was diagnosed with childhood-onset systemic lupus erythematosus. One year later, he was hospitalized with fever, myalgia, headache, arthritis, vomiting, dyspnea and was diagnosed with sepsis secondary to bronchopneumonia and meningitis. Blood culture identified Neisseria meningitidis serogroup Y. Despite antibiotics and intensive therapeutic measures, he died after 29 days of hospitalization. The autopsy revealed necrotic cardiomyocytes with dystrophic calcification and interstitial fibrosis. (AU)

• FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Support Opportunities: Research Projects - Thematic Grants