| Full text | |
| Author(s): |
Mastelic-Gavillet, Beatris
[1, 2, 3]
;
Vono, Maria
[1, 2]
;
Gonzalez-Dias, Patricia
[4]
;
Ferreira, Frederico Moraes
[5]
;
Cardozo, Lucas
[4]
;
Lambert, Paul-Henri
[1, 2]
;
Nakaya, I, Helder
;
Siegrist, Claire-Anne
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Univ Geneva, WHO Collaborating Ctr Vaccine Immunol, Dept Pathol Immunol, Geneva - Switzerland
[2] Univ Geneva, WHO Collaborating Ctr Vaccine Immunol, Dept Pediat, Geneva - Switzerland
[3] Univ Lausanne, Ludwig Ctr Canc Res, Ctr Expt Therapeut, Dept Oncol, Lausanne - Switzerland
[4] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[5] Univ Sao Paulo, Heart Inst, Sch Med, Lab Immunol, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | FRONTIERS IN IMMUNOLOGY; v. 10, AUG 13 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
T follicular helper (T-fh) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult T-fh cells at the transcriptomic level and demonstrated that the T-fh cell program is well-initiated in neonates although the T-f(h) gene-expression pattern (i.e., CXCR5, IL-21, BCL6, TBK1, STAT4, ASCL2, and c-MAF) is largely underrepresented as compared to adult T-fh cells. Importantly, we identified a TH2-bias of neonatal T-fh cells, with preferential differentiation toward short-lived pre-T-fh effector cells. Remarkably, adjuvantation with CpG-ODNs redirect neonatal pre-T-fh cells toward committed GC-T-fh cells, as illustrated by increased expression of T-fh signature genes and reduced expression of TH2-related genes. (AU) | |
| FAPESP's process: | 12/19278-6 - Systems biology of long non-coding RNAs |
| Grantee: | Helder Takashi Imoto Nakaya |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 17/50137-3 - Long noncoding RNA interplay with the host microbiome may determine mucosal influenza vaccine immunogenicity |
| Grantee: | Helder Takashi Imoto Nakaya |
| Support Opportunities: | Regular Research Grants |