Development of an experimental model of environmental Enteropathy
Grant number: | 17/50137-3 |
Support type: | Regular Research Grants |
Duration: | September 01, 2017 - August 31, 2019 |
Field of knowledge: | Biological Sciences - Immunology |
Cooperation agreement: | Imperial College, UK |
Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
Principal Investigator: | Helder Takashi Imoto Nakaya |
Grantee: | Helder Takashi Imoto Nakaya |
Principal investigator abroad: | Thushan De Silva |
Institution abroad: | Imperial College London, England |
Home Institution: | Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Associated research grant: | 12/19278-6 - Systems biology of long non-coding RNAs, AP.JP |
Abstract
This project will foster an independently funded collaboration between laboratories of Dr. Thushan de Silva and Dr. Beate Kampmann at Imperial College London and Dr. Helder Nakaya's group (FCF-USP) at USP. By applying a cutting edge systems biology approach to integrate nasopharyngeal microbiome, mucosal and blood transcriptome, immunological and clinical data, we will identify and investigate the putative role of long noncoding RNAs (IncRNAs) in vaccine-induced mucosal immunity. The exchange visits for data analysis/discussion sections, as well as the lectures/seminars and the workshop offered will provide the framework to spark the interaction between the groups. We will combine the expertise from Nakaya laboratory at USP and the data being generated via a clinical trial of LAIV (Live attenuted influenza vaccine) in children aged 24 - 59 months conducted at the MRC Unit the Gambia. Also, close links established during this proposal will enable Brazilian research to benefit from the well- established global health research network maintained by professor Kampmann, which includes the Centre for International Child Health (CICH) at Imperial College London recently established under her directorship. (AU)