Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate

Author(s)

Gonzales Garcia, Luhana Santos ^[1] ; Botazzo Delbem, Alberto Carlos ^[1] ; Pessan, Juliano Pelim ^[1] ; Silva, Matheus dos Passos ^[1] ; Souza Neto, Francisco Nunes ^[2] ; Gorup, Luiz Fernando ^[2] ; de Camargo, Emerson Rodrigues ^[2] ; Danelon, Marcelle ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Pediat Dent & Publ Hlth, Sch Dent, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, LIEC Dept Chem, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: CLINICAL ORAL INVESTIGATIONS; v. 23, n. 9, p. 3535-3542, SEP 2019.
• Web of Science Citations: 1

Abstract

Objective To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ. Methods This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6x/day). Blocks were treated 3x/day with the following toothpastes: no F/HMP/HMPnano (Placebo), conventional fluoride toothpaste, 1100 ppm F (1100F), 1100F + 0.5% micrometric HMP (1100F/HMP), and 1100F + 0.5% nano-sized HMP (1100F/HMPnano). The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (Delta KHN), and enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilms formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, followed by Student-Newman-Keuls' test (p < 0.001). Results 1100F/HMPnano promoted the lowest %SH and Delta KHN among all groups (p < 0.001). The addition of HMPnano to 1100F significantly increased Ca concentrations (p < 0.001). The 1100F/HMPnano promoted lower values of EPS when compared with 1100F (similar to 70%) (p < 0.001) and higher values of fluoride and calcium in the biofilms (p < 0.001). Conclusion 1100F/HMPnano demonstrated a greater protective effect against enamel demineralization and on the composition of biofilm in situ when compared to 1100F toothpaste. (AU)

• FAPESP's process: 16/03148-7 - Effect of addition of sodium hexametaphosphate nano-sized in fluoride toothpastes on the process of demineralization dental: study in situ
• Grantee: Matheus dos Passos Silva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation