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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain

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Author(s):
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Amarilla, Alberto A. [1, 2] ; Santos-Junior, Nilton Nascimento [3] ; Figueiredo, Mario Luis [1] ; Mesquita Luiz, Joao Paulo [4] ; Fumagalli, Marcilio Jorge [5] ; Colon, David F. [4] ; Lippi, Veronica [1] ; Alfonso, Helda Liz [1] ; Lima-Junior, Djalma S. [6] ; Trabuco, Amanda C. [1] ; Spinieli, Richard L. [7, 8] ; Desidera, Amanda C. [7] ; Leite-Panissi, Christie R. A. [7] ; Lauretti, Flavio [5] ; Sanchez Mendoza, Silvia Elena [9, 10] ; Araujo Silva, Cleide Lucia [11] ; Rego, Eduardo Magalhaes [9, 10] ; Galvao-Lima, Leonardo J. [12] ; Bassi, Gabriel S. [13] ; Penharvel Martins, Sandra L. B. [14] ; Manrique, Wilson Gomez [15] ; Alves-Filho, Jose Carlos [4] ; Cunha, Fernando Q. [4] ; Peng, Nias Y. G. [2] ; Modhiran, Naphak [2] ; Setoh, Yin Xiang [2] ; Khromykh, Alexander A. [2] ; Figueiredo, Luiz T. M. [13, 5] ; Aquino, Victor H. [1]
Total Authors: 29
Affiliation:
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[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Lab Virol, Ribeirao Preto, SP - Brazil
[2] Univ Queensland, Sch Chem & Mol Biosci, Australian Infect Dis Res Ctr, St Lucia, Qld - Australia
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, CRID, Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[7] Univ Sao Paulo, Sch Philosophy Sci & Literature Ribeirao Preto, Dept Psychol, Ribeirao Preto, SP - Brazil
[8] Univ Missouri, Dept Biomed Sci, Columbia, MO - USA
[9] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Hematol, Ribeirao Preto, SP - Brazil
[10] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Clin Oncol, Dept Internal Med, Ribeirao Preto, SP - Brazil
[11] Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto Reg Blood Ctr, Ribeirao Preto, SP - Brazil
[12] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Immunol, Ribeirao Preto, SP - Brazil
[13] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[14] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Ribeirao Preto, SP - Brazil
[15] Fed Univ Rondonia UNIR, Vet Med Course, Anim Hlth Lab, Rolim De Moura, RO - Brazil
Total Affiliations: 15
Document type: Journal article
Source: Journal of Infectious Diseases; v. 219, n. 12, p. 2015-2025, JUN 15 2019.
Web of Science Citations: 0
Abstract

Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975-1976 in Sao Paulo State, Brazil. Previous studies have shown an increased number of inflammatory macrophages in the central nervous system (CNS) of ROCV-infected mice, implying a role for macrophages in the pathogenesis of ROCV. Here, we show that ROCV infection results in increased expression of CCL2 in the blood and in infiltration of macrophages into the brain. Moreover, we show, using CCR2 knockout mice, that CCR2 expression is essential for macrophage infiltration in the brain during ROCV infection and that the lack of CCR2 results in increased disease severity and mortality. Thus, our findings show the protective role of CCR2-mediated infiltration of macrophages in the brain during ROCV infection. (AU)

FAPESP's process: 12/11169-3 - Analysis of participation the e protein in neuroinvasiveness and neurovirulence of Rocio virus in an animal model
Grantee:Victor Hugo Aquino Quintana
Support Opportunities: Regular Research Grants
FAPESP's process: 12/08778-8 - Analysis of participation the E protein in neuroinvasiveness and neurovirulence of Rocio virus in an animal model
Grantee:Alberto Anastacio Amarilla Ortiz
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/15548-4 - Study of viruses transmitted by rodents and arthropods: diagnosis and cross-protection
Grantee:Victor Hugo Aquino Quintana
Support Opportunities: Regular Research Grants
FAPESP's process: 14/02438-6 - Studies with Bunyaviridae that produce human disease
Grantee:Luiz Tadeu Moraes Figueiredo
Support Opportunities: Research Projects - Thematic Grants