| Full text | |
| Author(s): Show less - |
Almeida, Ewin B.
[1]
;
Silva, Karina P. H.
[1]
;
Paixao, Vitoria
[1]
;
do Amaral, Jonatas B.
[1]
;
Rossi, Marcelo
[1]
;
Xavier-Navarro, Roberta A.
[2]
;
Barros, Karina V.
[3]
;
Silveira, Vera L. F.
[4]
;
Vieira, Rodolfo P.
[5, 6, 7, 8]
;
Oliveira, Luis V. F.
[9]
;
Perez, Elizabeth C.
[10]
;
Jasiulionis, Miriam G.
[11]
;
Bachi, Andre L. L.
[1, 5]
Total Authors: 13
|
| Affiliation: Show less - | [1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol Head & Neck Surg, ENT Res Lab, BR-04039002 Sao Paulo - Brazil
[2] Samaritan Hosp Blood Bank, BR-01232910 Sao Paulo - Brazil
[3] Danone Nutr, BR-01311000 Sao Paulo - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Biol Sci, BR-09972270 Sao Paulo - Brazil
[5] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Paulo - Brazil
[6] Univ Brasil, Postgrad Program Bioengn, BR-08230030 Sao Paulo - Brazil
[7] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, BR-11015020 Sao Paulo - Brazil
[8] Anhembi Morumbi Univ, Sch Med, BR-12230002 Sao Paulo - Brazil
[9] Univ Ctr Anapolis UniEvangel, BR-75083515 Anapolis - Brazil
[10] Paulista Univ UNIP, Environm & Expt Pathol, BR-04057000 Sao Paulo - Brazil
[11] Fed Univ Sao Paulo UNIFESP, Pharmacol Dept, Lab Ontogeny & Epigenet, BR-04044020 Sao Paulo - Brazil
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 15 AUG 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B-4,B- and also that the peritumoral treatment with eicosapentaenoic acid and its product, leukotriene B-5, reduces the tumor development, the effect of the treatment by gavage with omega-3 and omega-6 in the tumor microenvironment favorable to melanoma growth associated with acute inflammation has never been studied. Methods: C57BL/6 mice were coinjected with 1 x 10(6) apoptotic cells plus 1 x 10(3) viable melanoma cells into the subcutaneous tissue and treated by gavage with omega-3-rich fish oil or omega-6-rich soybean oil or a mixture of these oils (1:1 ratio) during five consecutive days. Results: The treatment by gavage with a mixture of fish and soybean oils (1:1 ratio) both reduced the melanoma growth and the levels of leukotriene B-4 (LTB4), prostaglandin E-2 (PGE(2)), PGE(2)/prostaglandin E-3 (PGE(3)) ratio, and CXC ligand 1 (CXCL1) and increased the levels of interleukin 10 (IL-10) to IL-10/CXCL1 ratio in the melanoma microenvironment. Conclusion: The oral administration of a 1:1 mixture of fish oil and soybean oil was able to alter the release of inflammatory mediators that are essential for a microenvironment favorable to the melanoma growth in mice, whereas fish oil or soybean oil alone was ineffective. (AU) | |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/04845-3 - EFFECT OF DAILY INTAKE OF Lactobacillus casei Shirota (LcS) IN THE SYSTEMIC AND UPPER AIRWAYS IMMUNE RESPONSIVENESS OF AMATEUR MARATHON RUNNERS WHO PRESENT UPPER RESEPIRATORY SYMPTOMS |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Regular Research Grants |