Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam.

Author(s)

Maiara S. Borges ^[1] ; Carolina R. Biasetto ^[2] ; Vanessa M. Chapla ^[3] ; Samad N. Ebrahimi ^[4] ; Mayra F. Costa ^[5] ; Vanderlan S. Bolzani ^[6] ; Angela R. Araujo ^[7]

Affiliation

^[1] Universidade Estadual Paulista (Unesp). Instituto de Química - Brasil

^[2] Universidade Estadual Paulista (Unesp). Instituto de Química - Brasil

^[3] Universidade Federal do Tocantins (UFT) - Brasil

^[4] Shahid Beheshti University. Drugs Research Institute. Department of Phytochemistry, Medicinal Plants - Irã

^[5] Universidade Estadual Paulista (Unesp). Instituto de Química - Brasil

^[6] Universidade Estadual Paulista (Unesp). Instituto de Química - Brasil

^[7] Universidade Estadual Paulista (Unesp). Instituto de Química - Brasil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 30, n. 3, p. 522-527, 2019-03-00.

Abstract

A new compound named methyl (6S,7S,2E,4E)-6,7-dihydroxy-4,6-dimethyl octanoate was isolated from Saccharicola sp. using high performance liquid chromatography-solid phase extraction-transfer tube (HPLC-SPE-TT), together with four known compounds, fusaric acid, trans-4-hydroxymellein, thymidine and adenosine. Saccharicola sp. was isolated from the stems of Eugenia jambolana Lam. (Myrtaceae) as endophytic fungus. The structure of this novel substance was established based on its spectroscopic data, including 1H and 13C nuclear magnetic resonance (NMR), 2D NMR techniques and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). This paper deals with the first report of its kind on this compound in Saccharicola sp. (AU)

• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants