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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intrafollicular barriers and cellular interactions during ovarian follicle development

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Author(s):
Andrade, Gabriella Mamede [1] ; del Collado, Maite [1] ; Meirelles, Flavio Vieira [1] ; da Silveira, Juliano Coelho [1] ; Perecin, Felipe [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Vet Med, Fac Anim Sci & Food Engn, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ANIMAL REPRODUCTION; v. 16, n. 3, p. 485-496, JUL-SEP 2019.
Web of Science Citations: 0
Abstract

Follicles are composed of different interdependent cell types including oocytes, cumulus, granulosa, and theca cells. Follicular cells and oocytes exchange signaling molecules from the beginning of the development of the primordial follicles until the moment of ovulation. The follicular structure transforms during folliculogenesis; barriers form between the germ and the somatic follicular cells, and between the somatic follicular cells. As such, communication systems need to adapt to maintain the exchange of signaling molecules. Two critical barriers are established at different stages of development: the zona pellucida, separating the oocyte and the cumulus cells limiting the communication through specific connections, and the antrum, separating subpopulations of follicular cells. In both situations, communication is maintained either by the development of specialized connections as transzonal projections or by paracrine signaling and trafficking of extracellular vesicles through the follicular fluid. The bidirectional communication between the oocytes and the follicle cells is vital for driving folliculogenesis and oogenesis. These communication systems are associated with essential functions related to follicular development, oocyte competence, and embryonic quality. Here, we discuss the formation of the zona pellucida and antrum during folliculogenesis, and their importance in follicle and oocyte development. Moreover, this review discusses the current knowledge on the cellular mechanisms such as the movement of molecules via transzonal projections, and the exchange of extracellular vesicles by follicular cells to overcome these barriers to support female gamete development. Finally, we highlight the undiscovered aspects related to intrafollicular communication among the germ and somatic cells, and between the somatic follicular cells and give our perspective on manipulating the above-mentioned cellular communication to improve reproductive technologies. (AU)

FAPESP's process: 18/01431-9 - PI3K-Akt signaling pathway effect in oocyte maturation and early embryo development in cattle
Grantee:Gabriella Mamede Andrade
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/13155-6 - Mechanisms of lipid accumulation in oocytes under metabolic altered environments: in vitro maturation and obesity
Grantee:Felipe Perecin
Support type: Regular Research Grants
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/22887-0 - Cell-secreted vesicles containing miRNAs modulate epigenetic changes during in vitro culture of bovine gametes and embryos
Grantee:Juliano Coelho da Silveira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 17/19825-0 - Mechanisms of oocyte lipid accumulation in obesity
Grantee:Maite Del Collado Barrondo
Support type: Scholarships in Brazil - Post-Doctorate