Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

Author(s)

Della-Felice, Franco ^{[1, 2]} ; Sarotti, Ariel M. ^[3] ; Krische, Michael J. ^[2] ; Pilli, Ronaldo A. ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Texas Austin, Dept Chem, Austin, TX 78712 - USA

^[3] Univ Nacl Rosario, CONICET, Inst Quim Rosario, Fac Ciencias Bioquim & Farmaceut, Suipacha 531, S2002LRK, Rosario, Santa Fe - Argentina

• Document type: Journal article
• Source: Journal of the American Chemical Society; v. 141, n. 35, p. 13778-13782, SEP 4 2019.
• Web of Science Citations: 1

Abstract

The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members. (AU)

• FAPESP's process: 17/18487-4 - Synthesis and structural validation of phosdiecin A
• Grantee: Franco Della Felice
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• FAPESP's process: 16/12541-4 - A biomimetic approach to the total synthesis of Stemona alkaloids
• Grantee: Ronaldo Aloise Pilli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/25474-8 - Synthesis and biological evualuation of Brevipolide A, Cryptomoskatone F1 and related compounds
• Grantee: Franco Della Felice
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)