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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development

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de Oliveira, Diogo N. [1] ; Lima, Estela O. [1] ; Melo, Carlos F. O. R. [1] ; Delafiori, Jeany [1] ; Guerreiro, Tatiane M. [1] ; Rodrigues, Rafael G. M. [1] ; Morishita, Karen N. [1] ; Silveira, Cynthia [2] ; Muraro, Stefanie Primon [3] ; de Souza, Gabriela Fabiano [3] ; Vieira, Aline [3] ; Silva, Antonio [4] ; Batista, Rosangela F. [4] ; Doriqui, Maria J. R. [4] ; Sousa, Patricia S. [4] ; Milanez, Guilherme P. [3] ; Proenca-Modena, Jose L. [3] ; Cavalcanti, Denise P. [2] ; Catharino, Rodrigo R. [1]
Total Authors: 19
[1] Univ Estadual Campinas, Sch Pharmaceut Sci, INNOVARE Biomarkers Lab, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Med Genet Dept, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Biol Inst, Dept Genet Evolut Microbiol & Immunol, Emerging Viruses Study Lab, Campinas, SP - Brazil
[4] Univ Fed Maranhao, Publ Hlth Dept, Sao Luis - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, SEP 20 2019.
Web of Science Citations: 0

Zika virus (ZIKV) has emerged as one of the most medically relevant viral infections of the past decades; the devastating effects of this virus over the developing brain are a major matter of concern during pregnancy. Although the connection with congenital malformations are well documented, the mechanisms by which ZIKV reach the central nervous system (CNS) and the causes of impaired cortical growth in affected fetuses need to be better addressed. We performed a non-invasive, meta bolomicsbased screening of saliva from infants with congenital Zika syndrome (CZS), born from mothers that were infected with ZIKV during pregnancy. We were able to identify three biomarkers that suggest that this population suffered from an important inflammatory process; with the detection of mediators associated with glial activation, we propose that microcephaly is a product of immune response to the virus, as well as excitotoxicity mechanisms, which remain ongoing even after birth. (AU)

FAPESP's process: 18/03321-6 - A comprehensive metabolomics and lipidomics overview of plasma from patients with Alzheimer's Disease for screening dementia-linked biomarkers
Grantee:Carlos Fernando Odir Rodrigues Melo
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
Grantee:Aníbal Eugênio Vercesi
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/17066-2 - Metabolomics and lipidomics the Zika virus, from mosquitoes to the patient
Grantee:Carlos Fernando Odir Rodrigues Melo
Support type: Scholarships in Brazil - Doctorate