Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

Author(s)

Marques Furtado de Mendonca-Louzeiro, Maria Raquel ^[1] ; Annichino-Bizzacchi, Joyce Maria ^{[2, 3]} ; Magna, Luis Alberto ^[4] ; Picoli Quaino, Susan Kelly ^[2] ; Benetti-Pinto, Cristina Laguna ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Med Sci, Dept Gynecol & Obstet, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Campinas Blood Ctr, Hemostasis Lab, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Dept Clin Med, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Sch Med Sci, Dept Med Genet, Sao Paulo - Brazil

• Document type: Journal article
• Source: Fertility and Sterility; v. 99, n. 6, p. 1786-1790, MAY 2013.
• Web of Science Citations: 6

Abstract

Objective: To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index. Design: Cross-sectional study. Setting: Tertiary teaching hospital. Patient(s): Forty-five women with PCOS and 45 controls paired for age (+/- 2 years) and body mass index (+/- 2 kg/m(2)). Intervention(s): Clinical evaluation and venipuncture. Main Outcome Measure(s): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test. Result(s): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups. Conclusion(s): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability. (c) 2013 by American Society for Reproductive Medicine. (AU)

• FAPESP's process: 10/11707-0 - Markers of the haemostatic system and their correlation with clinical and laboratorial parameters in women with polycystic ovarian syndrome
• Grantee: Cristina Laguna Benetti Pinto
• Support Opportunities: Regular Research Grants