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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

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Author(s):
Marques Furtado de Mendonca-Louzeiro, Maria Raquel [1] ; Annichino-Bizzacchi, Joyce Maria [2, 3] ; Magna, Luis Alberto [4] ; Picoli Quaino, Susan Kelly [2] ; Benetti-Pinto, Cristina Laguna [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Dept Gynecol & Obstet, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Campinas Blood Ctr, Hemostasis Lab, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Dept Clin Med, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Med Genet, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Fertility and Sterility; v. 99, n. 6, p. 1786-1790, MAY 2013.
Web of Science Citations: 6
Abstract

Objective: To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index. Design: Cross-sectional study. Setting: Tertiary teaching hospital. Patient(s): Forty-five women with PCOS and 45 controls paired for age (+/- 2 years) and body mass index (+/- 2 kg/m(2)). Intervention(s): Clinical evaluation and venipuncture. Main Outcome Measure(s): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test. Result(s): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups. Conclusion(s): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability. (c) 2013 by American Society for Reproductive Medicine. (AU)

FAPESP's process: 10/11707-0 - Markers of the haemostatic system and their correlation with clinical and laboratorial parameters in women with polycystic ovarian syndrome
Grantee:Cristina Laguna Benetti Pinto
Support Opportunities: Regular Research Grants