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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Growth hormone/STAT5 signaling in proopiomelanocortin neurons regulates glucoprivic hyperphagia

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Quaresma, Paula G. F. [1] ; Teixeira, Pryscila D. S. [1] ; Furigo, Isadora C. [1] ; Wasinski, Frederick [1] ; Couto, Gisele C. [1] ; Frazao, Renata [2] ; List, Edward O. [3, 4] ; Kopchick, John J. [3, 4] ; Donato Jr, Jose
Total Authors: 9
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508900 Sao Paulo, SP - Brazil
[3] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 - USA
[4] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 - USA
Total Affiliations: 4
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 498, DEC 1 2019.
Web of Science Citations: 2

Several hypothalamic neuronal populations are directly responsive to growth hormone (GH) and central GH action regulates glucose and energy homeostasis. However, the potential role of GH signaling in proopiomelanocortin (POMC) neurons has not been studied yet. Thus, we investigated whether POMC neurons are responsive to GH and if ablation of GH receptor (GHR) or STAT5 in POMC cells leads to metabolic imbalances. Approximately 60% of POMC neurons of the arcuate nucleus exhibited STAT5 phosphorylation after intracerebroventricular GH injection. Ablation of GHR or STAT5 in POMC cells did not affect energy or glucose homeostasis. However, glucoprivic hyperphagia was blunted in male and female GHR knockout mice, and in male POMC-specific STAT5 knockout mice. Additionally, the absence of GHR in POMC neurons decreased glycemia during prolonged food restriction in male mice. Thus, GH action in POMC neurons regulates glucoprivic hyperphagia as well as blood glucose levels during prolonged food restriction. (AU)

FAPESP's process: 17/25281-3 - Effects of growth hormone on POMC, cholinergic and hypothalamic paraventricular nucleus neurons: implications for energy and glycemic metabolism control
Grantee:Paula Gabriele Fernandes Quaresma Bergonsi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/20897-3 - Role of orexin neurons as mediators of the central effects induced by growth hormone
Grantee:Frederick Wasinski
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/21840-8 - Growth hormone signaling in the brain as a mediator of puberty and fertility
Grantee:Renata Frazão
Support type: Regular Research Grants
FAPESP's process: 17/04006-4 - The importance of growth hormone's action on NPY/AgRP neurons
Grantee:Gisele Cristina Lopes Couto Spiri
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/02983-2 - The role of growth hormone in the brain: relevance for neural functions and in disease
Grantee:Jose Donato Junior
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/09679-4 - Central effects of growth hormone on energetic metabolism and glicemic control
Grantee:Isadora Clivatti Furigo
Support type: Scholarships in Brazil - Post-Doctorate