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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive food compounds, epigenetics and chronic disease prevention: Focus on early-life interventions with polyphenols

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Author(s):
Aparecida Ribeiro Silva, Livia Beatriz [1] ; Pinheiro-Castro, Natalia [1] ; Novaes, Gabriela Machado [1] ; Laiber Pascoal, Gabriela de Freitas [1] ; Ong, Thomas Prates [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Food Res Ctr, Sch Pharmaceut Sci, Dept Food Sci, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Food Research International; v. 125, NOV 2019.
Web of Science Citations: 0
Abstract

Consumption of bioactive compounds such as polyphenols, isothiocyanates, sulfur-containing compounds and terpenoids, found in fruits and vegetables, is associated with prevention of chronic disease. These bioactive food compounds elicit their protective effects through complex mechanisms at the cellular and molecular, including epigenetic levels. According to the Developmental Origins of Health and Disease (DOHaD) paradigm, in utero exposure to stressors such as malnutrition through maternal diet would impair fetal development and epigenetically program increased risk of metabolic diseases and some cancers in adult life. In addition, a role for fathers' diet during preconception on their offspring health and chronic disease susceptibility has also emerged. This highlights early life as a promising window of opportunity for starting dietary interventions focusing on preventing chronic diseases. However, knowledge on the potential beneficial impact of early life exposure to bioactive food compounds is limited. Among the studies that have investigated bioactive food compounds in the context of DOHaD, most have focused on the impact of dietary polyphenols. Thus, in this review we discuss experimental evidence supporting a role for the dietary polyphenols resveratrol, genistein, epigallocatechin-3-gallate and anthocyanins in chronic disease prevention considering a perspective from early-life interventions through maternal and paternal diets and focusing on epigenetics as a potential underlying mechanism. (AU)

FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC