Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients

Author(s)

Pedroso, Juliana de Fatima ^[1] ; Lotfollahi, Zahra ^[2] ; Albattarni, Ghadeer ^[2] ; Schulz, Maiara Arrruda ^[3] ; Monteiro, Andrea ^[4] ; Sehnem, Andre Luiz ^[2] ; Gidlund, Magnus Ake ^[4] ; Figueiredo Neto, Antonio Martins ^[2] ; Neves Jardini, Maria Aparecida ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Sci & Technol, Dept Diag & Surg, Sao Jose Dos Campos - Brazil

^[2] Univ Sao Paulo, Inst Phys, Sao Paulo - Brazil

^[3] Labvi Valle, Tech Manageress, Sao Jose Dos Campos - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 9, NOV 6 2019.
• Web of Science Citations: 0

Abstract

The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supragingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases. (AU)

• FAPESP's process: 16/24531-3 - Structural and biophysics properties of native and modified lipoproteins
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/50983-3 - INCT 2014: complex fluids
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/07340-5 - Structural characterisation of lipoproteins
• Grantee: Zahra Lotfollahi
• Support Opportunities: Scholarships in Brazil - Post-Doctoral