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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lower genital tract infections in young female juvenile idiopathic arthritis patients

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Author(s):
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Ferreira, V, Gabriela R. ; Tomioka, Renato B. [1, 2] ; Queiroz, Ligia B. [3] ; Kozu, Katia [4] ; Aikawa, Nadia E. [4, 1] ; Sallum, Adriana M. E. [4] ; Serafini, Paulo [2] ; Tacla, Maricy [2] ; Baracat, Edmund C. [2] ; Pereira, Rosa M. R. [1] ; Bonfa, Eloisa [1] ; Silva, Clovis A. [4, 1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Rheumatol Div, Av Dr Eneas Carvalho Aguiar 647, BR-05403000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Discipline Gynecol, Fac Med, Hosp Clin HCFMUSP, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Adolescent Unit, Childrens Inst, Sao Paulo, SP - Brazil
[4] Ferreira, Gabriela R., V, Univ Sao Paulo, Pediat Rheumatol Unit, Childrens Inst, Hosp Clin HCFMUSP, Fac Med, Av Dr Eneas Carvalho Aguiar 647, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ADVANCES IN RHEUMATOLOGY; v. 59, n. 1 NOV 15 2019.
Web of Science Citations: 0
Abstract

Background To evaluate human papillomavirus (HPV), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in juvenile idiopathic arthritis (JIA) patients. Methods After exclusion, 33 female adolescent and young JIA patients (ILAR criteria) and 28 healthy controls were selected for this study. Demographic data, gynecological, sexual function, cervical cytology and histological abnormalities were evaluated. JIA clinical/laboratorial parameters and treatment were also assessed. HPV-DNA, CT-DNA and NG-DNA testing in cervical specimens were performed by Hybrid Capture 2 assays. Results The mean current age was similar in JIA patients and controls (23.3 +/- 6.24 vs. 26.1 +/- 6.03 years, p = 0.09). The frequencies of sexual intercourse (76% vs. 89%, p = 0.201) and abnormal cervical cytology (24% vs. 11%, p = 0.201) were similar in JIA compared to controls. The higher frequency of HPV infection in JIA patients than controls (30% vs. 11%, p = 0.155) did not reach statistical significance. CT (0% vs. 7%, p = 0.207) and NG infections (0% vs. 4%, p = 0.459) were also alike in both groups. Further evaluation of JIA patients with abnormal and normal cervical cytology showed that the former group had a higher frequency of HPV infection (87% vs. 12%, p = 0.0002) with a low frequency of HPV vaccination (0% vs. 8%, p = 1.0). No differences were evidenced between these two JIA groups regarding demographic data, sexual function and clinical/laboratorial parameters. The frequencies of methotrexate (p = 0.206) and biological agent use (p = 0.238) were similar in both JIA groups. Conclusions To our knowledge, this was the first study to assess lower genital infections in JIA patients allowing the identification of HPV as main cause of cervical dysplasia. Methotrexate and biological agents do not seem to increase risk of lower genital tract infections in JIA patients. (AU)

FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
Grantee:Eloisa Silva Dutra de Oliveira Bonfá
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/14806-0 - Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis
Grantee:Clovis Artur Almeida da Silva
Support Opportunities: Regular Research Grants