Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract

Full text
Author(s):
Show less -
KAMILLE D. SPERA [1] ; PATRÍCIA A. FIGUEIREDO [2] ; PAMELA C.E SANTOS [3] ; FERNANDO C. BARBOSA [4] ; CAIO P. ALVES [5] ; ANNE LÍGIA DOKKEDAL [6] ; LUIZ LEONARDO SALDANHA [7] ; LUCIANA P. SILVA [8] ; CARLOS ROGÉRIO FIGUEIREDO [9] ; PAULO CESAR FERREIRA [10] ; REGILDO M.G. DA SILVA [11]
Total Authors: 11
Affiliation:
Show less -
[1] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[2] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[3] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[4] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[5] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[6] Universidade Estadual Paulista/UNESP. Faculdade de Ciências. Departamento de Ciências Biológicas - Brasil
[7] Universidade Estadual Paulista/UNESP. Faculdade de Ciências. Departamento de Ciências Biológicas - Brasil
[8] Fundação Educacional do Município de Assis/FEMA - Brasil
[9] Universidade Federal de São Paulo/UNIFESP. Departamento de Microbiologia, Imunologia e Parasitologia. Unidade de Oncologia Experimental/UNONEX - Brasil
[10] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
[11] Universidade Estadual Paulista/UNESP. Faculdade de Ciências e Letras de Assis. Departamento de Biotecnologia - Brasil
Total Affiliations: 11
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 91, n. 4 2019-12-02.
Abstract

Abstract: Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic extract from H. courbaril seeds. Therefore, for the cytotoxicity test an anti-melanoma assay was performed in B16F10 strain cells. The genotoxicity and antigenotoxicity was evaluated in bone marrow cells (Permit number: 002/2010) of mice, the antioxidant activity was determined by the DPPH test and the total flavonoid content was also determined. The hydroethanolic extract showed antigenotoxic effect and antioxidant activity. It was verified that total flavonoid content was 442.25±18.03 mg RE/g dry extract. HPLC-PAD chromatogram revealed presence of flavones as majority compound in evaluated extract. The results allowed us to also infer that the hydroethanolic extract from seeds shows cytotoxic activity against B16F10 melanoma cells line and it has dose-and-time-dependency. (AU)

FAPESP's process: 11/15430-5 - Assessing the potential antioxidant, cytotoxic and sunscreen of extracts and fractions of Hymenaea courbaril L. and Hymenaea stigonocarpa Mart
Grantee:Patrícia Aparecida Figueiredo
Support Opportunities: Scholarships in Brazil - Master