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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

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Author(s):
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Ferreira, V, Filipe ; Souza, Lucas P. [1] ; Martins, Thais M. M. [2] ; Lopes, Joao H. [3] ; Mattos, Bruno D. [4] ; Mariano, Marcos [5] ; Pinheiro, Ivanei F. [5, 6] ; Valverde, Thalita M. [7] ; Livi, Sebastien [8] ; Camilli, Jose A. [1] ; Goes, Alfredo M. [9] ; Gouveia, Rubia F. [5] ; Lona, Liliane M. F. [6] ; Rojas, Orlando J. [4]
Total Authors: 14
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, BR-13083862 Campinas, SP - Brazil
[2] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Morphol, BR-31270901 Belo Horizonte, MG - Brazil
[3] Technol Inst Aeronaut ITA, Div Fundamental Sci IEF, Dept Chem, BR-12228900 Sao Jose Dos Campos, SP - Brazil
[4] Ferreira, Filipe, V, Aalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, POB 16300, Aalto 00076 - Finland
[5] Ferreira, Filipe, V, Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Nanotechnol Natl Lab LNNano, BR-13083970 Campinas, SP - Brazil
[6] Ferreira, Filipe, V, Univ Estadual Campinas, UNICAMP, Sch Chem Engn, BR-13083970 Campinas, SP - Brazil
[7] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG - Brazil
[8] Ferreira, Filipe, V, Univ Lyon, CNRS, Ingn Mat Polymeres, INSA Lyon, UMR 5223, F-69621 Villeurbanne - France
[9] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Pathol, BR-31270901 Belo Horizonte, MG - Brazil
Total Affiliations: 9
Document type: Journal article
Source: NANOSCALE; v. 11, n. 42, p. 19842-19849, NOV 14 2019.
Web of Science Citations: 0
Abstract

A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated with cell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The results pave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering. (AU)

FAPESP's process: 18/12831-8 - In situ synthesis of biodegradable polymers using nanocrystalline and Microfibrillated cellulose and lignin with no functionalization
Grantee:Liliane Maria Ferrareso Lona
Support type: Regular Research Grants
FAPESP's process: 18/16851-3 - Nanocellulose foams filled with 45S5 Bioglass®: a three-dimensional environmentally friendly scaffold for bone tissue engineering
Grantee:Filipe Vargas Ferreira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/09588-9 - Functionalization of cellulose nanocrystals to developing biodegradable nanocomposites PBAT/CNC
Grantee:Filipe Vargas Ferreira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 10/05394-9 - Bioglasses derived from 45S5: effects of Nb2O5 or surface modification with Ca2+ on the glass structure and bioactivity
Grantee:João Henrique Lopes
Support type: Scholarships in Brazil - Doctorate