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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism

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Author(s):
Tavares, Mariana Rosolen [1, 2] ; Lemes, Simone Ferreira [1] ; de Fante, Thais [1] ; de Miera, Cristina Saenz ; Betim Pavan, Isadora Carolina [1, 2] ; Neves Bezerra, Rosangela Maria [2] ; Prada, Patricia Oliveira [3] ; Torsoni, Marcio Alberto [1] ; Elias, Carol Fuzeti [4] ; Simabuco, Fernando Moreira [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Campinas UNICAMP, Sch Appl Sci FCA, Lab Metab Disorders LABDIME, Limeira, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Appl Sci FCA, Multidisciplinary Lab Food & Hlth LABMAS, Limeira, SP - Brazil
[3] Univ Campinas UNICAMP, Sch Appl Sci FCA, Lab Mol Res Obes LABIMO, Limeira, SP - Brazil
[4] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 - USA
Total Affiliations: 4
Document type: Journal article
Source: Journal of Endocrinology; v. 244, n. 1, p. 71-82, JAN 2020.
Web of Science Citations: 0
Abstract

The mTOR/S6Ks signaling is one of the intracellular pathways important for metabolic control, acting both peripherally and centrally. In the hypothalamus, mTOR/S6Ks axis mediates the action of leptin and insulin and can modulate the expression of neuropeptides. We analyzed the role of different S6Ks isoforms in the hypothalamic regulation of metabolism. We observed decreased food intake and decreased expression of agouti-related peptide (AgRP) following intracerebroventricular (icv) injections of adenoviral-mediated overexpression of three different S6Ks isoforms. Moreover, mice overexpressing p70-S6K1 in undefined periventricular hypothalamic neurons presented changes in glucose metabolism, as an increase in gluconeogenesis. To further evaluate the hypothalamic role of a less-studied S6K isoform, p54-S6K2, we used a Cre-LoxP approach to specifically overexpress it in AgRP neurons. Our findings demonstrate the potential participation of S6K2 in AgRP neurons regulating feeding behavior. (AU)

FAPESP's process: 12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases
Grantee:Fernando Moreira Simabuco
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 13/22696-7 - Modulation of the S6Ks expression in the central nervous system and their effect in obesity
Grantee:Mariana Rosolen Tavares
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/14818-9 - Study of molecular targets important for the control of cancer metabolism: the mTOR/S6K pathway as a central role
Grantee:Fernando Moreira Simabuco
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 18/07018-6 - Role of hypothalamic S6Ks in metabolic regulation
Grantee:Mariana Rosolen Tavares
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 15/24475-3 - Modulation of expression of S6Ks in the central nervous system and its effects in obesity
Grantee:Mariana Rosolen Tavares
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/06457-0 - Leaves and stalks of beet (Beta vulgaris L.): characterization and effects of the antioxidant capacity in obese and dyslipidemic
Grantee:Rosângela Maria Neves Bezerra
Support Opportunities: Regular Research Grants