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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding membrane remodelling initiated by photosensitized lipid oxidation

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Author(s):
Tsubone, Tayana Mazin [1] ; Baptista, Mauricio S. [2] ; Itri, Rosangela [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Phys, Appl Phys Dept, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Chem, Biochem Dept, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Biophysical Chemistry; v. 254, NOV 2019.
Web of Science Citations: 2
Abstract

In this review, we describe how photooxidation changes membrane properties that can ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the presence of reactive oxygen species such as singlet oxygen and by direct reactions of lipids with a photosensitizer in the excited state. Indeed, lipid oxidation triggers chemical transformations that can alter lipid packing; change the membrane surface area, thickness and elastic modulus; and induce pore formation and phase separation. Here, we highlight how lipid hydroperoxides promote membrane remodelling and phase separation. Further, we emphasize the alterations caused by truncated oxidized lipids that lead to increased membrane permeability. Finally, the consequences of lipid photooxidation on cell functions are also discussed. (AU)

FAPESP's process: 16/23071-9 - Photosensitization in lysosomal mimetic membranes to investigate the cell death mechanism related to autophagy.
Grantee:Tayana Mazin Tsubone
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/20107-7 - Lipid oxidation in membrane and cell biophysics: from functional nanosensors to impact on amyloid formation. Application of advanced fluorescence, X-ray scattering and microscopy techniques
Grantee:Rosangela Itri
Support type: Regular Research Grants