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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emerging CAR T cell therapies: clinical landscape and patent technological routes

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Author(s):
Picanco-Castro, Virginia [1] ; Pereira, Cristiano Goncalves [2] ; Swiech, Kamilla [3, 1] ; Ribeiro Malmegrim, Kelen Cristina [3, 1] ; Covas, Dimas Tadeu [1] ; Porto, Geciane Silveira [2, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ctr Cell Based Therapy CTC, Reg Blood Ctr Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Econ Business Adm & Accounting, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Inst Adv Studies, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: HUMAN VACCINES & IMMUNOTHERAPEUTICS; v. 16, n. 6 DEC 2019.
Web of Science Citations: 1
Abstract

The purpose of this study is to mine CAR-T patents and therapies under development, to design a landscape of the sector and to understand key therapy segments and their current trends. The study analyzed the entire market, consisting of 1624 patent families and 509 biologics under development, to depict an overview of the CAR-T therapies and their state of the art. Our results showed cutting-edge inventions, the major players, the dynamics of cooperation among institutions, the progress of the therapies' generation over the years and future innovation pathways. CAR-T therapies are transforming the current scenario for cancer treatment, and this study reveals the picture of what we can likely expect ahead in order to assist scientists at the academy and industry to improve their research strategies. (AU)

FAPESP's process: 15/13816-4 - Scientific and Technological Productivity of the Brazilian Research Infrastructures
Grantee:Sérgio Kannebley Júnior
Support Opportunities: Regular Research Grants
FAPESP's process: 17/25364-6 - Mapping of Cooperation Networks and Technological Trends in Biotechnology Patents through Social Network Analysis
Grantee:Geciane Silveira Porto
Support Opportunities: Regular Research Grants
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/22500-8 - Identification of patent-based technological trends in red biotechnology
Grantee:Cristiano Gonçalves Pereira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy
Grantee:Dimas Tadeu Covas
Support Opportunities: Research Projects - Thematic Grants