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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of Resistance Gene Prevalence in Whole-Genome Sequenced Enterobacteriales from Brazil

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Author(s):
Vilela, Felipe Pinheiro [1] ; Falcao, Juliana Pfrimer [1] ; Campioni, Fabio [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Av Cafe S-N Bloco S Sala 41, BR-14040903 Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MICROBIAL DRUG RESISTANCE; v. 26, n. 6 NOV 2019.
Web of Science Citations: 0
Abstract

Enterobacteriales is an order of bacteria responsible for community and hospital-acquired infections related to high rates of antimicrobial resistance and increased treatment costs, morbidity, and mortality globally. The aims of this study were to analyze the frequency of the resistance genes detected and distribution over the years and sources of isolation in sequenced Enterobacteriales strains isolated in Brazil and available at the Pathogen Detection website. The presence of resistance genes was analyzed in 1,507 whole-genome sequenced strains of 19 Enterobacteriales species. A total of 58.0% of the strains presented resistance genes to at least one antimicrobial class and 684 strains presented a multidrug-resistant (MDR) profile. Resistance genes to 14 classes of antimicrobials were detected. Aminoglycosides presented the most prevalent and diverse resistance genes, while the sulfonamide resistance gene, sul2, was the most prevalent among the strains studied. The presence of resistance genes from 14 different antimicrobial classes, the high levels of MDR strains, and the detection of genes related to clinical and veterinary-used drugs reinforce the necessity of more efficient control measures. Moreover, it warns for the necessity of the rational use of antimicrobials in veterinary and clinical situations in Brazil, since contaminated food may act as a vehicle for human infections. (AU)

FAPESP's process: 19/06947-6 - Molecular characterization of the genotypic diversity, resistance profile and pathogenic potential of Salmonella Infantis strains isolated from multiple sources in Brazil
Grantee:Felipe Pinheiro Vilela
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/24716-3 - Sequencing of the Genome, transcriptoma and phenotypic analysis of Campylobacter coli strains isolated from different sources in Brazil
Grantee:Juliana Pfrimer Falcão
Support Opportunities: Regular Research Grants