Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antitumor Potential of Seaweed Derived-Endophytic Fungi

Full text
Author(s):
Teixeira, Thaiz Rodrigues [1] ; dos Santos, Gustavo Souza [1] ; Armstrong, Lorene [2] ; Colepicolo, Pio [3] ; Debonsi, Hosana Maria [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, BR-84030900 Ponta Grossa, PR - Brazil
[3] Univ Sao Paulo, Dept Biochem, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: ANTIBIOTICS-BASEL; v. 8, n. 4 DEC 2019.
Web of Science Citations: 0
Abstract

The marine environment presents a high biodiversity and a valuable source of bioactive compounds with therapeutic and biotechnological potential. Among the organisms present in marine environment, the endophytic fungi isolated from seaweed stand out. These microorganisms have aroused interest in the scientific community regarding its various activities such as antiviral, antimicrobial, antioxidant, photoprotective, cytotoxic, genotoxic, anti-inflammatory, and anticancer, besides establishing important ecological relations with its hosts. Anticancer molecules derived from marine natural sources are a promising target against different types of cancer. The disease's high rates of morbidity and mortality affect millions of people world wild and the search for new therapeutic alternatives is needed. Thus, this review partially summarizes the methodologies for the isolation of seaweed-derived endophytic fungi, as well as describes the anticancer compounds isolated from such microorganisms, reported in the literature from 2009 to the present. In addition, it describes how some biotechnological processes can help in the discovery of bioactive compounds, especially with anticancer activity. (AU)

FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 16/06931-4 - Biodiversity of marine algae and metabolites of economical impact
Grantee:Pio Colepicolo Neto
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants